Phillip P Knowles
Overview
Explore the profile of Phillip P Knowles including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
334
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Recent Articles
1.
Adams S, Purkiss A, Knowles P, Nans A, Briggs D, Borg A, et al.
Structure
. 2021 Jan;
29(7):694-708.e7.
PMID: 33484636
RET receptor tyrosine kinase plays vital developmental and neuroprotective roles in metazoans. GDNF family ligands (GFLs) when bound to cognate GFRα co-receptors recognize and activate RET stimulating its cytoplasmic kinase...
2.
Nakaoku T, Kohno T, Araki M, Niho S, Chauhan R, Knowles P, et al.
Nat Commun
. 2018 Feb;
9(1):625.
PMID: 29434222
Resistance to vandetanib, a type I RET kinase inhibitor, developed in a patient with metastatic lung adenocarcinoma harboring a CCDC6-RET fusion that initially exhibited a response to treatment. The resistant...
3.
Plenker D, Riedel M, Bragelmann J, Dammert M, Chauhan R, Knowles P, et al.
Sci Transl Med
. 2017 Jun;
9(394).
PMID: 28615362
Oncogenic fusion events have been identified in a broad range of tumors. Among them, rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas. We provide...
4.
Goodman K, Kjaer S, Beuron F, Knowles P, Nawrotek A, Burns E, et al.
Cell Rep
. 2014 Sep;
8(6):1894-1904.
PMID: 25242331
The RET receptor tyrosine kinase is essential to vertebrate development and implicated in multiple human diseases. RET binds a cell surface bipartite ligand comprising a GDNF family ligand and a...
5.
Kjaer S, Linch M, Purkiss A, Kostelecky B, Knowles P, Rosse C, et al.
Biochem J
. 2013 Feb;
451(2):329-42.
PMID: 23418854
The aPKC [atypical PKC (protein kinase C)] isoforms ι and ζ play crucial roles in the formation and maintenance of cell polarity and represent attractive anti-oncogenic drug targets in Ras-dependent...
6.
Boeda B, Knowles P, Briggs D, Murray-Rust J, Soriano E, Garvalov B, et al.
J Biol Chem
. 2011 Feb;
286(13):11543-54.
PMID: 21278383
Actin-related proteins (Arps) are a highly conserved family of proteins that have extensive sequence and structural similarity to actin. All characterized Arps are components of large multimeric complexes associated with...
7.
Mologni L, Rostagno R, Brussolo S, Knowles P, Kjaer S, Murray-Rust J, et al.
Bioorg Med Chem
. 2010 Feb;
18(4):1482-96.
PMID: 20117004
The synthesis, structure-activity relationships (SAR) and structural data of a series of indolin-2-one inhibitors of RET tyrosine kinase are described. These compounds were designed to explore the available space around...
8.
Kirk R, Laman H, Knowles P, Murray-Rust J, Lomonosov M, Meziane E, et al.
J Biol Chem
. 2008 May;
283(32):22325-35.
PMID: 18495667
F-box proteins are the substrate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases. Here we report a structural relationship between Fbxo7, a component of the SCF(Fbxo7) E3 ligase,...
9.
Roces L, Knowles P, Fox G, Juanhuix J, Scaplehorn N, Way M, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2008 Mar;
64(Pt 3):190-2.
PMID: 18323605
The cysteine-based protein phosphatase H1L was the first reported dual-specificity protein phosphatase. H1L is encapsidated within the vaccinia virus and is required for successful host infection and for the production...
10.
Knowles P, Murray-Rust J, Kjaer S, Scott R, Hanrahan S, Santoro M, et al.
J Biol Chem
. 2006 Aug;
281(44):33577-87.
PMID: 16928683
The RET proto-oncogene encodes a receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family of ligands. Loss-of-function mutations in RET are implicated in Hirschsprung disease, whereas activating mutations...