Peter J Parker
Overview
Explore the profile of Peter J Parker including associated specialties, affiliations and a list of published articles.
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Articles
129
Citations
4188
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Recent Articles
1.
Earl C, Cobbaut M, Barros-Carvalho A, Ivanova M, Briggs D, Morais-de-Sa E, et al.
Nat Struct Mol Biol
. 2025 Jan;
PMID: 39762628
The mutually antagonistic relationship of atypical protein kinase C (aPKC) and partitioning-defective protein 6 (Par6) with the substrate lethal (2) giant larvae (Lgl) is essential for regulating polarity across many...
2.
Conduit S, Pearce W, Bhamra A, Bilanges B, Bozal-Basterra L, Foukas L, et al.
Nat Commun
. 2024 Aug;
15(1):7181.
PMID: 39168978
Primary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia...
3.
Iyer R, Needham S, Galdadas I, Davis B, Roberts S, Man R, et al.
Nat Commun
. 2024 Mar;
15(1):2130.
PMID: 38503739
The Epidermal Growth Factor Receptor (EGFR) is frequently found to be mutated in non-small cell lung cancer. Oncogenic EGFR has been successfully targeted by tyrosine kinase inhibitors, but acquired drug...
4.
Cobbaut M, Parker P, McDonald N
Biochem J
. 2023 Dec;
480(24):2037-2044.
PMID: 38100320
Atypical protein kinase Cs (aPKCs) are part of the PKC family of protein kinases and are atypical because they don't respond to the canonical PKC activators diacylglycerol (DAG) and Ca2+....
5.
Soliman T, Keifenheim D, Parker P, Clarke D
J Cell Biol
. 2023 Nov;
222(12).
PMID: 37955972
DNA Topoisomerase IIA (Topo IIA) is an enzyme that alters the topological state of DNA and is essential for the separation of replicated sister chromatids and the integrity of cell...
6.
Cobbaut M, McDonald N, Parker P
J Biol Chem
. 2023 May;
299(7):104847.
PMID: 37211093
Atypical PKCs are cell polarity kinases that operate at the plasma membrane where they function within multiple molecular complexes to contribute to the establishment and maintenance of polarity. In contrast...
7.
Dugan M, Ferguson L, Hertz N, Chalkley R, Burlingame A, Shokat K, et al.
Mol Cell Proteomics
. 2023 Mar;
22(4):100522.
PMID: 36863607
PKC epsilon (PKCε) plays important roles in behavioral responses to alcohol and in anxiety-like behavior in rodents, making it a potential drug target for reducing alcohol consumption and anxiety. Identifying...
8.
Sanchez-Magraner L, Gumuzio J, Miles J, Quimi N, Del Prado P, Abad-Villar M, et al.
J Clin Oncol
. 2023 Feb;
41(14):2561-2570.
PMID: 36821809
Purpose: In many cancers, the expression of immunomodulatory ligands leads to immunoevasion, as exemplified by the interaction of PD-L1 with PD-1 on tumor-infiltrating lymphocytes. Profound advances in cancer treatments have...
9.
Marshall J, Cull J, Alharbi H, Zaw Thin M, Cooper S, Barrington C, et al.
Biochem J
. 2022 Jun;
479(13):1467-1486.
PMID: 35730579
The protein kinase PKN2 is required for embryonic development and PKN2 knockout mice die as a result of failure in the expansion of mesoderm, cardiac development and neural tube closure....
10.
Nikou S, Zhou C, Griffiths J, Kotowicz N, Coleman B, Green M, et al.
Sci Signal
. 2022 Apr;
15(728):eabj6915.
PMID: 35380879
The fungal pathogen secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase...