Neil Q McDonald
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Explore the profile of Neil Q McDonald including associated specialties, affiliations and a list of published articles.
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63
Citations
5535
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Recent Articles
1.
Earl C, Cobbaut M, Barros-Carvalho A, Ivanova M, Briggs D, Morais-de-Sa E, et al.
Nat Struct Mol Biol
. 2025 Jan;
PMID: 39762628
The mutually antagonistic relationship of atypical protein kinase C (aPKC) and partitioning-defective protein 6 (Par6) with the substrate lethal (2) giant larvae (Lgl) is essential for regulating polarity across many...
2.
Conduit S, Pearce W, Bhamra A, Bilanges B, Bozal-Basterra L, Foukas L, et al.
Nat Commun
. 2024 Aug;
15(1):7181.
PMID: 39168978
Primary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia...
3.
Bland T, Hirani N, Briggs D, Rossetto R, Ng K, Taylor I, et al.
EMBO J
. 2024 Jun;
43(15):3214-3239.
PMID: 38907033
Cell polarity networks are defined by quantitative features of their constituent feedback circuits, which must be tuned to enable robust and stable polarization, while also ensuring that networks remain responsive...
4.
Al Rawi S, Simpson L, Agnarsdottir G, McDonald N, Chernuha V, Elpeleg O, et al.
FEBS J
. 2024 Mar;
291(12):2565-2589.
PMID: 38466799
Mutations in FBXO7 have been discovered to be associated with an atypical parkinsonism. We report here a new homozygous missense mutation in a paediatric patient that causes an L250P substitution...
5.
Cobbaut M, Parker P, McDonald N
Biochem J
. 2023 Dec;
480(24):2037-2044.
PMID: 38100320
Atypical protein kinase Cs (aPKCs) are part of the PKC family of protein kinases and are atypical because they don't respond to the canonical PKC activators diacylglycerol (DAG) and Ca2+....
6.
Cobbaut M, McDonald N, Parker P
J Biol Chem
. 2023 May;
299(7):104847.
PMID: 37211093
Atypical PKCs are cell polarity kinases that operate at the plasma membrane where they function within multiple molecular complexes to contribute to the establishment and maintenance of polarity. In contrast...
7.
Bax B, Sutormin D, McDonald N, Burley G, Shelkovnikova T
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36232843
Topoisomerases are essential enzymes that recognize and modify the topology of DNA to allow DNA replication and transcription to take place. Topoisomerases are divided into type I topoisomerases, that cleave...
8.
Rhymes E, Tosolini A, Fellows A, Mahy W, McDonald N, Schiavo G
Cell Death Dis
. 2022 Jul;
13(7):584.
PMID: 35798698
Deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (ALS), including SOD1 mice. Evidence suggests that rescuing these deficits prevents disease...
9.
Zhang L, Moccia M, Briggs D, Bharate J, Lakkaniga N, Knowles P, et al.
J Med Chem
. 2022 Jan;
65(2):1536-1551.
PMID: 35081714
Mutations of the rearranged during transfection (RET) kinase are frequently reported in cancer, which make it as an attractive therapeutic target. Herein, we discovered a series of N-trisubstituted pyrimidine derivatives...
10.
Martini S, Davis K, Faraway R, Elze L, Lockwood N, Jones A, et al.
Nat Commun
. 2021 Nov;
12(1):6934.
PMID: 34836941
The PKCε-regulated genome protective pathway provides transformed cells a failsafe to successfully complete mitosis. Despite the necessary role for Aurora B in this programme, it is unclear whether its requirement...