Jayne S Danska
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Explore the profile of Jayne S Danska including associated specialties, affiliations and a list of published articles.
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49
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2849
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Recent Articles
21.
Paun A, Danska J
Pediatr Diabetes
. 2016 Aug;
17(7):469-477.
PMID: 27484959
The prevalence of type 1 and type 2 diabetes have both risen dramatically over the last 50 years. Recent findings point towards the gut microbiota as a potential contributor to...
22.
Paun A, Yau C, Danska J
J Autoimmun
. 2016 Feb;
71:10-8.
PMID: 26908163
Type 1 diabetes (T1D) is an autoimmune disease resulting from T cell-mediated destruction of the insulin-secreting pancreatic beta cells. During the past 50 years T1D incidence has increased dramatically in...
23.
Paun A, Danska J
Curr Opin Immunol
. 2015 Oct;
37:34-9.
PMID: 26460968
The trillions of microorganisms populating the mammalian mucosal surfaces (i.e. the microbiome) participate in the development and function of the host immune system that acts to balance clearance of pathogens...
24.
Motta V, Markle J, Gulban O, Mortin-Toth S, Liao K, Mogridge J, et al.
J Immunol
. 2015 May;
194(12):5663-73.
PMID: 25964492
Type 1 diabetes in the NOD mouse model has been linked to >30 insulin-dependent diabetes (Idd) susceptibility loci. Idd4 on chromosome 11 consists of two subloci, Idd4.1 and Idd4.2. Using...
25.
Danska J
Sci Transl Med
. 2014 Oct;
6(258):258fs40.
PMID: 25320230
Some funding agencies now require consideration of sex and gender in preclinical research, a policy that heralds opportunities and challenges for researchers.
26.
Wong A, Mortin-Toth S, Sung M, Canty A, Gulban O, Greaves D, et al.
J Immunol
. 2014 Oct;
193(10):4833-44.
PMID: 25305319
The signal regulatory protein (SIRP) locus encodes a family of paired receptors that mediate both activating and inhibitory signals and is associated with type 1 diabetes (T1D) risk. The NOD...
27.
Markle J, Frank D, Adeli K, von Bergen M, Danska J
Gut Microbes
. 2014 Jul;
5(4):485-93.
PMID: 25007153
Despite growing evidence for a causal role of environmental factors in autoimmune diseases including the rise in disease frequencies over the past several decades we lack an understanding of how...
28.
Johnson R, Papp E, Grandal I, Kowalski P, Nutter L, Wong R, et al.
Genes Dev
. 2014 Jun;
28(11):1179-90.
PMID: 24888589
During V(D)J recombination of immunoglobulin genes, p53 and nonhomologous end-joining (NHEJ) suppress aberrant rejoining of DNA double-strand breaks induced by recombinase-activating genes (Rags)-1/2, thus maintaining genomic stability and limiting malignant...
29.
Perova T, Grandal I, Nutter L, Papp E, Matei I, Beyene J, et al.
Sci Transl Med
. 2014 May;
6(236):236ra62.
PMID: 24828076
Intensified and central nervous system (CNS)-directed chemotherapy has improved outcomes for pediatric B cell acute lymphoblastic leukemia (B-ALL) but confers treatment-related morbidities. Moreover, many patients suffer relapses, underscoring the need...
30.
Nuvolone M, Kana V, Hutter G, Sakata D, Mortin-Toth S, Russo G, et al.
J Exp Med
. 2013 Oct;
210(12):2539-52.
PMID: 24145514
Prnp(-/-) mice lack the prion protein PrP(C) and are resistant to prion infections, but variable phenotypes have been reported in Prnp(-/-) mice and the physiological function of PrP(C) remains poorly...