Cynthia J Guidos
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Explore the profile of Cynthia J Guidos including associated specialties, affiliations and a list of published articles.
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48
Citations
1769
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Recent Articles
1.
Tracey L, El-Maklizi M, Sokolowski D, Gams M, Brooke-Bisschop T, Ruston J, et al.
Sci Rep
. 2025 Mar;
15(1):8827.
PMID: 40087379
The transcription factor Prdm14 is a potent oncogene implicated in the initiation of many cancers. PRDM14 resets and maintains the pluripotent state in normal cells, but the molecular mechanisms through...
2.
Granato A, Xie Q, Wong A, Yau C, Noseworthy R, Chen T, et al.
Diabetes
. 2025 Feb;
PMID: 39982433
Obesity in childhood is associated with adulthood obesity, type 2 diabetes (T2D), and future metabolic complications. The gut microbiome is a modifier of host metabolic function with altered bacterial composition...
3.
Scott O, Visuvanathan S, Reddy E, Mahamed D, Gu B, Roifman C, et al.
Front Immunol
. 2023 Jun;
14:1183273.
PMID: 37275873
Introduction: Humans with gain-of-function (GOF) mutations in STAT1 (Signal Transducer and Activator of Transcription 1), a potent immune regulator, experience frequent infections. About one-third, especially those with DNA-binding domain (DBD)...
4.
Fortin J, Chiang M, Meydan C, Foox J, Ramachandran P, Leca J, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2208176120.
PMID: 36652477
Mutations in , and are recurrently observed in myeloid neoplasms. and encode isocitrate dehydrogenase isoforms, which normally catalyze the conversion of isocitrate to α-ketoglutarate (α-KG). Oncogenic mutations confer neomorphic activity,...
5.
Rajakumar S, Grandal I, Minden M, Hitzler J, Guidos C, Danska J
Cell Rep Med
. 2022 Jan;
2(12):100470.
PMID: 35028611
Acute lymphoblastic leukemia (ALL) dissemination to the central nervous system (CNS) is a challenging clinical problem whose underlying mechanisms are poorly understood. Here, we show that primary human ALL samples...
6.
Vanner R, Dobson S, Gan O, McLeod J, Schoof E, Grandal I, et al.
Blood Cancer Discov
. 2022 Jan;
3(1):16-31.
PMID: 35019858
Central nervous system (CNS) dissemination of B-precursor acute lymphoblastic leukemia (B-ALL) has poor prognosis and remains a therapeutic challenge. Here we performed targeted DNA sequencing as well as transcriptional and...
7.
Mer A, Heath E, Madani Tonekaboni S, Dogan-Artun N, Kadambat Nair S, Murison A, et al.
Nat Commun
. 2021 Feb;
12(1):1054.
PMID: 33594052
In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic entity in the revised World...
8.
Xu W, Snell L, Guo M, Boukhaled G, Macleod B, Li M, et al.
Immunity
. 2021 Jan;
54(3):526-541.e7.
PMID: 33515487
Chronic viral infections increase severity of Mycobacterium tuberculosis (Mtb) coinfection. Here, we examined how chronic viral infections alter the pulmonary microenvironment to foster coinfection and worsen disease severity. We developed...
9.
Rajakumar S, Papp E, Lee K, Grandal I, Merico D, Liu C, et al.
Sci Transl Med
. 2020 Sep;
12(561).
PMID: 32938796
Although most children survive B cell acute lymphoblastic leukemia (B-ALL), they frequently experience long-term, treatment-related health problems, including osteopenia and osteonecrosis. Because some children present with fractures at ALL diagnosis,...
10.
Galati M, Hodel K, Gams M, Sudhaman S, Bridge T, Zahurancik W, et al.
Cancer Res
. 2020 Sep;
80(24):5606-5618.
PMID: 32938641
mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype-phenotype correlation, and therapeutic considerations. In this study, we establish mouse models harboring cancer-associated mutations...