Jason Karch
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Explore the profile of Jason Karch including associated specialties, affiliations and a list of published articles.
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33
Citations
2407
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Recent Articles
1.
Qi X, Xiong F, Xiao J, Muthukumarasamy K, Altuntas Y, Zhong Y, et al.
bioRxiv
. 2025 Feb;
PMID: 39975327
Background: Changes in mitochondria have been implicated in atrial fibrillation (AF), but their manifestations and significance are poorly understood. Here, we studied changes in mitochondrial morphology and function during AF...
2.
Patel P, Mendoza A, Ramirez D, Robichaux D, Molkentin J, Karch J
Sci Adv
. 2024 Dec;
10(50):eadp7444.
PMID: 39661674
The mitochondrial permeability transition pore (mPTP) is implicated in cardiac ischemia-reperfusion (I/R) injury. During I/R, elevated mitochondrial Ca triggers mPTP opening, leading to necrotic cell death. Although nonessential regulators of...
3.
Massey S, Kongchan N, Gao Y, Chaudhury A, Olokpa E, Karch J, et al.
J Biol Chem
. 2024 Sep;
300(11):107826.
PMID: 39343007
Epithelial to mesenchymal transition (EMT) is believed to be a principal factor contributing to cancer metastasis. The post-transcriptional and post-translational mechanisms underlying EMT are comparatively underexplored. We previously demonstrated that...
4.
Mendoza A, Patel P, Robichaux D, Ramirez D, Karch J
Circ Res
. 2024 Apr;
134(10):1292-1305.
PMID: 38618716
Background: During myocardial ischemia/reperfusion (I/R) injury, high levels of matrix Ca and reactive oxygen species (ROS) induce the opening of the mitochondrial permeability transition pore (mPTP), which causes mitochondrial dysfunction...
5.
Song J, Wu J, Robichaux D, Li T, Wang S, Arredondo Sancristobal M, et al.
Cells
. 2024 Jan;
13(2).
PMID: 38247800
High-protein diets (HPDs) offer health benefits, such as weight management and improved metabolic profiles. The effects of HPD on cardiac arrhythmogenesis remain unclear. Atrial fibrillation (AF), the most common arrhythmia,...
6.
Bround M, Havens J, York A, Sargent M, Karch J, Molkentin J
Sci Adv
. 2023 Aug;
9(34):eadi2767.
PMID: 37624892
Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-reperfusion injury in the heart and several degenerative diseases, including muscular dystrophy (MD). MD is a family of genetic disorders characterized by...
7.
Bernardi P, Gerle C, Halestrap A, Jonas E, Karch J, Mnatsakanyan N, et al.
Cell Death Differ
. 2023 Jul;
30(8):1869-1885.
PMID: 37460667
The mitochondrial permeability transition (mPT) describes a Ca-dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size. It...
8.
Robichaux D, Harata M, Murphy E, Karch J
J Mol Cell Cardiol
. 2022 Nov;
174:47-55.
PMID: 36410526
Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is triggered by...
9.
Mendoza A, Karch J
Front Aging
. 2022 Aug;
3:951417.
PMID: 35958271
The process of aging strongly correlates with maladaptive architectural, mechanical, and biochemical alterations that contribute to the decline in cardiac function. Consequently, aging is a major risk factor for the...
10.
Mendoza A, Karch J
Methods Mol Biol
. 2022 Jun;
2497:129-140.
PMID: 35771440
The loss of mitochondrial cristae integrity and mitochondrial swelling are hallmarks of multiple forms of necrotic cell death. One of the most well-studied and relevant inducers of mitochondrial swelling is...