Jeffery D Molkentin
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Explore the profile of Jeffery D Molkentin including associated specialties, affiliations and a list of published articles.
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373
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Recent Articles
1.
Patel P, Mendoza A, Ramirez D, Robichaux D, Molkentin J, Karch J
Sci Adv
. 2024 Dec;
10(50):eadp7444.
PMID: 39661674
The mitochondrial permeability transition pore (mPTP) is implicated in cardiac ischemia-reperfusion (I/R) injury. During I/R, elevated mitochondrial Ca triggers mPTP opening, leading to necrotic cell death. Although nonessential regulators of...
2.
Johansen A, Kasam R, Vagnozzi R, Lin S, Gomez-Arroyo J, Shittu A, et al.
Circ Res
. 2024 Dec;
136(1):44-58.
PMID: 39629593
Background: TCF21 (transcription factor 21) is a bHLH (basic helix-loop-helix) protein required for the developmental specification of cardiac fibroblasts (CFs) from epicardial progenitor cells that surround the embryonic heart. In...
3.
Huo J, Molkentin J
Cell Calcium
. 2024 Oct;
124:102959.
PMID: 39405656
Fluctuations in mitochondrial matrix Ca plays a critical role in matching energy production to cellular demand through direct effects on oxidative phosphorylation and ATP production. Disruption in mitochondrial Ca homeostasis,...
4.
Tang X, Wei W, Sun Y, Weaver T, Nakayasu E, Clair G, et al.
J Clin Invest
. 2024 Oct;
134(23).
PMID: 39405113
The most common mutation in surfactant protein C gene (SFTPC), SFTPCI73T, causes interstitial lung disease with few therapeutic options. We previously demonstrated that EMC3, an important component of the multiprotein...
5.
Meng Q, Yang B, Qiao Y, Wu Y, Chen J, Lin X, et al.
Circulation
. 2024 Sep;
150(11):899-901.
PMID: 39250538
No abstract available.
6.
Bowers S, Meng Q, Molkentin J
Nat Cardiovasc Res
. 2024 May;
1(4):312-321.
PMID: 38765890
Cell communication is needed for organ function and stress responses, especially in the heart. Cardiac fibroblasts, cardiomyocytes, immune cells, and endothelial cells comprise the major cell types in ventricular myocardium...
7.
Huo J, Molkentin J
Trends Endocrinol Metab
. 2024 Apr;
35(10):918-928.
PMID: 38688781
Skeletal muscle has a major impact on total body metabolism and obesity, and is characterized by dynamic regulation of substrate utilization. While it is accepted that acute increases in mitochondrial...
8.
Vanhoutte D, Schips T, Minerath R, Huo J, Kavuri N, Prasad V, et al.
Cell Rep
. 2024 Apr;
43(5):114149.
PMID: 38678560
Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have profound muscle atrophy with age-dependent decreases...
9.
Bround M, Abay E, Huo J, Havens J, York A, Bers D, et al.
Sci Rep
. 2024 Mar;
14(1):6751.
PMID: 38514795
Mitochondrial Ca overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca influx across the sarcolemma that...
10.
Grimes K, Maillet M, Swoboda C, Bowers S, Millay D, Molkentin J
Am J Physiol Heart Circ Physiol
. 2023 Nov;
326(1):H180-H189.
PMID: 37999644
During select pathological conditions, the heart can hypertrophy and remodel in either a dilated or concentric ventricular geometry, which is associated with lengthening or widening of cardiomyocytes, respectively. The mitogen-activated...