Bryan D Maliken
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Explore the profile of Bryan D Maliken including associated specialties, affiliations and a list of published articles.
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19
Citations
1307
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Recent Articles
1.
Hochberg J, Sohal A, Handa P, Maliken B, Kim T, Wang K, et al.
JHEP Rep
. 2023 May;
5(6):100729.
PMID: 37179785
Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease that can lead to end-stage liver disease and cholangiocarcinoma. High-dose ursodeoxycholic acid (hd-UDCA, 28-30 mg/kg/day) was...
2.
Alam P, Maliken B, Jones S, Ivey M, Wu Z, Wang Y, et al.
Int J Mol Sci
. 2021 Dec;
22(23).
PMID: 34884909
The limited ability of mammalian adult cardiomyocytes to proliferate following an injury to the heart, such as myocardial infarction, is a major factor that results in adverse fibrotic and myocardial...
3.
Alam P, Maliken B, Ivey M, Jones S, Kanisicak O
J Vis Exp
. 2020 Oct;
(164).
PMID: 33104067
Ex vivo culture of the adult mammalian cardiomyocytes (CMs) presents the most relevant experimental system for the in vitro study of cardiac biology. Adult mammalian CMs are terminally differentiated cells...
4.
Khalil H, Kanisicak O, Vagnozzi R, Johansen A, Maliken B, Prasad V, et al.
JCI Insight
. 2019 Aug;
4(15):e128722.
PMID: 31393098
Collagen production in the adult heart is thought to be regulated by the fibroblast, although cardiomyocytes and endothelial cells also express multiple collagen mRNAs. Molecular chaperones are required for procollagen...
5.
Alam P, Haile B, Arif M, Pandey R, Rokvic M, Nieman M, et al.
J Am Heart Assoc
. 2019 Jul;
8(15):e012089.
PMID: 31315484
Background Myocardial infarction results in a large-scale cardiomyocyte loss and heart failure due to subsequent pathological remodeling. Whereas zebrafish and neonatal mice have evident cardiomyocyte expansion following injury, adult mammalian...
6.
Handa P, Thomas S, Morgan-Stevenson V, Maliken B, Gochanour E, Boukhar S, et al.
J Leukoc Biol
. 2019 Mar;
105(5):1015-1026.
PMID: 30835899
We have previously demonstrated that iron overload in hepatic reticuloendothelial system cells (RES) is associated with severe nonalcoholic steatohepatitis (NASH) and advanced fibrosis in patients with nonalcoholic fatty liver disease...
7.
Maliken B, Molkentin J
Circulation
. 2018 Oct;
138(8):806-808.
PMID: 30359129
No abstract available.
8.
Maliken B, Kanisicak O, Karch J, Khalil H, Fu X, Boyer J, et al.
Circulation
. 2018 Apr;
138(10):1012-1024.
PMID: 29666070
Background: Although c-Kit adult progenitor cells were initially reported to produce new cardiomyocytes in the heart, recent genetic evidence suggests that such events are exceedingly rare. However, to determine if...
9.
Fu X, Khalil H, Kanisicak O, Boyer J, Vagnozzi R, Maliken B, et al.
J Clin Invest
. 2018 Apr;
128(5):2127-2143.
PMID: 29664017
Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by...
10.
Karch J, Schips T, Maliken B, Brody M, Sargent M, Kanisicak O, et al.
Elife
. 2017 Nov;
6.
PMID: 29148970
Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are...