Michelle A Sargent
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Explore the profile of Michelle A Sargent including associated specialties, affiliations and a list of published articles.
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56
Citations
3631
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Recent Articles
1.
Johansen A, Kasam R, Vagnozzi R, Lin S, Gomez-Arroyo J, Shittu A, et al.
Circ Res
. 2024 Dec;
136(1):44-58.
PMID: 39629593
Background: TCF21 (transcription factor 21) is a bHLH (basic helix-loop-helix) protein required for the developmental specification of cardiac fibroblasts (CFs) from epicardial progenitor cells that surround the embryonic heart. In...
2.
Vanhoutte D, Schips T, Minerath R, Huo J, Kavuri N, Prasad V, et al.
Cell Rep
. 2024 Apr;
43(5):114149.
PMID: 38678560
Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have profound muscle atrophy with age-dependent decreases...
3.
Bowers S, Meng Q, Kuwabara Y, Huo J, Minerath R, York A, et al.
Cells
. 2023 Sep;
12(17).
PMID: 37681905
Rationale: The adult cardiac extracellular matrix (ECM) is largely comprised of type I collagen. In addition to serving as the primary structural support component of the cardiac ECM, type I...
4.
Bround M, Havens J, York A, Sargent M, Karch J, Molkentin J
Sci Adv
. 2023 Aug;
9(34):eadi2767.
PMID: 37624892
Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-reperfusion injury in the heart and several degenerative diseases, including muscular dystrophy (MD). MD is a family of genetic disorders characterized by...
5.
Kuwabara Y, York A, Lin S, Sargent M, Grimes K, Pirruccello J, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(19):e2213696120.
PMID: 37126682
To better understand the genetic basis of heart disease, we identified a variant in the () gene that generates a R1243H missense change and predisposes to cardiac remodeling across multiple...
6.
Grimes K, Prasad V, Huo J, Kuwabara Y, Vanhoutte D, Baldwin T, et al.
Front Physiol
. 2023 Feb;
14:1054169.
PMID: 36733907
The ribosomal protein L3-like (RPL3L) is a heart and skeletal muscle-specific ribosomal protein and paralogue of the more ubiquitously expressed RPL3 protein. Mutations in the human gene are linked to...
7.
Yan R, Cigliola V, Oonk K, Petrover Z, DeLuca S, Wolfson D, et al.
Cell Stem Cell
. 2022 Dec;
30(1):96-111.e6.
PMID: 36516837
The efficacy and safety of gene-therapy strategies for indications like tissue damage hinge on precision; yet, current methods afford little spatial or temporal control of payload delivery. Here, we find...
8.
Vagnozzi R, Kasam R, Sargent M, Molkentin J
Circulation
. 2021 Jul;
144(4):328-331.
PMID: 34310160
No abstract available.
9.
Vanhoutte D, Schips T, Vo A, Grimes K, Baldwin T, Brody M, et al.
Nat Commun
. 2021 Jun;
12(1):3928.
PMID: 34168130
The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced mediators of cellular attachment dynamics and extracellular matrix protein production. Here we show that Thbs1, but not Thbs2,...
10.
Huo J, Lu S, Kwong J, Bround M, Grimes K, Sargent M, et al.
Circ Res
. 2020 Apr;
127(3):379-390.
PMID: 32299299
Rationale: Mitochondrial Ca loading augments oxidative metabolism to match functional demands during times of increased work or injury. However, mitochondrial Ca overload also directly causes mitochondrial rupture and cardiomyocyte death...