Jason Karch
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Explore the profile of Jason Karch including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
2407
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Recent Articles
11.
Hulsurkar M, Lahiri S, Karch J, Wang M, Wehrens X
Expert Opin Ther Targets
. 2022 Apr;
26(4):303-317.
PMID: 35426759
Introduction: Abnormal calcium signaling between organelles such as the sarcoplasmic reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium serves as a secondary messenger mediating inter-organellar...
12.
Patel P, Mendoza A, Robichaux D, Wang M, Wehrens X, Karch J
Front Cell Dev Biol
. 2021 Dec;
9:765973.
PMID: 34926454
Mitochondrial permeability transition pore (MPTP)-dependent necrosis contributes to numerous pathologies in the heart, brain, and skeletal muscle. The MPTP is a non-selective pore in the inner mitochondrial membrane that is...
13.
Wang Y, Liu H, Sun N, Li J, Peng X, Jia Y, et al.
Oxid Med Cell Longev
. 2021 Nov;
2021():5391706.
PMID: 34745418
Ischemia-reperfusion injury (IRI) is defined as the total combined damage that occurs during a period of ischemia and following the recovery of blood flow. Oxidative stress, mitochondrial dysfunction, and an...
14.
Martens M, Karch J, Gordon J
Biochim Biophys Acta Mol Basis Dis
. 2021 Oct;
1868(1):166297.
PMID: 34718119
Cell death is now understood to be a highly regulated process that contributes to normal development and tissue homeostasis, alongside its role in the etiology of various pathological conditions. Through...
15.
Chiang D, Lahiri S, Wang G, Karch J, Wang M, Jung S, et al.
Proteomes
. 2021 Jul;
9(2).
PMID: 34200203
Hyperphosphorylation of the calcium release channel/ryanodine receptor type 2 (RyR2) at serine 2814 (S2814) is associated with multiple cardiac diseases including atrial fibrillation and heart failure. Despite recent advances, the...
16.
Patel P, Karch J
Int Rev Cell Mol Biol
. 2020 May;
353:153-209.
PMID: 32381175
The adult heart is a post-mitotic terminally differentiated organ; therefore, beyond development, cardiomyocyte cell death is maladaptive. Heart disease is the leading cause of death in the world and aberrant...
17.
Karch J, Bround M, Khalil H, Sargent M, Latchman N, Terada N, et al.
Sci Adv
. 2019 Sep;
5(8):eaaw4597.
PMID: 31489369
The mitochondrial permeability transition pore (MPTP) has resisted molecular identification. The original model of the MPTP that proposed the adenine nucleotide translocator (ANT) as the inner membrane pore-forming component was...
18.
Schips T, Vanhoutte D, Vo A, Correll R, Brody M, Khalil H, et al.
Nat Commun
. 2019 Jan;
10(1):76.
PMID: 30622267
Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated muscle from disease by enhancing sarcolemmal...
19.
Maliken B, Kanisicak O, Karch J, Khalil H, Fu X, Boyer J, et al.
Circulation
. 2018 Apr;
138(10):1012-1024.
PMID: 29666070
Background: Although c-Kit adult progenitor cells were initially reported to produce new cardiomyocytes in the heart, recent genetic evidence suggests that such events are exceedingly rare. However, to determine if...
20.
van Berlo J, Kanisicak O, Maillet M, Vagnozzi R, Karch J, Lin S, et al.
Nature
. 2018 Mar;
555(7697):E18.
PMID: 29565361
No abstract available.