Hardev Pandha
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Explore the profile of Hardev Pandha including associated specialties, affiliations and a list of published articles.
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148
Citations
4130
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Recent Articles
1.
Morgan R, Smith C, Pandha H
Methods Mol Biol
. 2025 Jan;
2889:139-153.
PMID: 39745610
The HOX and PBX genes encode transcription factors that have key roles in development and cancer, both independently and as a heterodimer within a complex of proteins that recognizes specific...
2.
Maylin Z, Smith C, Classen A, Asim M, Pandha H, Wang Y
Cells
. 2024 Dec;
13(23).
PMID: 39682746
Neuroendocrine prostate cancer (NEPC), an aggressive and lethal subtype of prostate cancer (PCa), often arises as a resistance mechanism in patients undergoing hormone therapy for prostate adenocarcinoma. NEPC is associated...
3.
Lin H, Mazumder H, Sarkar I, Huang P, Eeles R, Kote-Jarai Z, et al.
Sci Rep
. 2024 Aug;
14(1):18677.
PMID: 39134575
Single nucleotide polymorphism (SNP) interactions are the key to improving polygenic risk scores. Previous studies reported several significant SNP-SNP interaction pairs that shared a common SNP to form a cluster,...
4.
Wilford T, Bartlett P, Schlag A, Jasaitis L, Pandha H, Pierce A, et al.
Bioanalysis
. 2024 Jul;
16(14):757-769.
PMID: 38957926
Endogenous interferents can cause nonselectivity in ligand binding pharmacokinetic assays, leading to inaccurate quantification of drug concentrations. We describe the development of a Gyrolab immunoassay to quantify a new modality,...
5.
Michael A, Wilson W, Sunshine S, Annels N, Harrop R, Blount D, et al.
Int J Gynecol Cancer
. 2024 May;
34(8):1225-1231.
PMID: 38760075
Background: Immunotherapy directed at 5T4 tumor antigen may delay the need for further chemotherapy. An attenuated modified vaccinia Ankara virus containing the gene encoding for 5T4 (MVA-5T4) was studied in...
6.
Zareian N, Eremin O, Pandha H, Baird R, Kwatra V, Funingana G, et al.
Exp Biol Med (Maywood)
. 2024 Mar;
249:10021.
PMID: 38463391
The presence of inhibitory immune cells and difficulty in generating activated effector T cells remain obstacles to development of effective cancer vaccines. We designed a vaccine regimen combining human telomerase...
7.
Spick M, Muazzam A, Pandha H, Michael A, Gethings L, Hughes C, et al.
Heliyon
. 2023 Dec;
9(12):e22604.
PMID: 38076065
There is an unmet need for improved diagnostic testing and risk prediction for cases of prostate cancer (PCa) to improve care and reduce overtreatment of indolent disease. Here we have...
8.
Challoner B, Woolston A, Lau D, Buzzetti M, Fong C, Barber L, et al.
J Pathol
. 2023 Nov;
262(2):226-239.
PMID: 37964706
Mismatch repair-deficient (MMRd) colorectal cancers (CRCs) have high mutation burdens, which make these tumours immunogenic and many respond to immune checkpoint inhibitors. The MMRd hypermutator phenotype may also promote intratumour...
9.
Wang A, Shen J, Rodriguez A, Saunders E, Chen F, Janivara R, et al.
Nat Genet
. 2023 Nov;
55(12):2065-2074.
PMID: 37945903
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry...
10.
Annels N, Denyer M, Nicol D, Hazell S, Silvanto A, Crockett M, et al.
Cancer Immunol Immunother
. 2023 Nov;
72(12):4221-4234.
PMID: 37940720
Renal cell carcinoma is an immunogenic tumour with a prominent dysfunctional immune cell infiltrate, unable to control tumour growth. Although tyrosine kinase inhibitors and immunotherapy have improved the outlook for...