Fredrik Wiklund
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Explore the profile of Fredrik Wiklund including associated specialties, affiliations and a list of published articles.
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214
Citations
12325
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Recent Articles
1.
Ugalde-Morales E, Wilf R, Pluta J, Ploner A, Fan M, Damra M, et al.
Am J Hum Genet
. 2025 Feb;
112(3):630-643.
PMID: 39999848
Transcriptome-wide association studies (TWASs) have the potential to identify susceptibility genes associated with testicular germ cell tumors (TGCTs). We conducted a comprehensive TGCT TWAS by integrating genome-wide association study (GWAS)...
2.
Srinivasan S, Kryza T, Bock N, Tse B, Sokolowski K, Janaththani P, et al.
Nat Commun
. 2024 Nov;
15(1):9587.
PMID: 39505858
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA)...
3.
Lin H, Mazumder H, Sarkar I, Huang P, Eeles R, Kote-Jarai Z, et al.
Sci Rep
. 2024 Aug;
14(1):18677.
PMID: 39134575
Single nucleotide polymorphism (SNP) interactions are the key to improving polygenic risk scores. Previous studies reported several significant SNP-SNP interaction pairs that shared a common SNP to form a cluster,...
4.
Vigneswaran H, Eklund M, Discacciati A, Nordstrom T, Hubbard R, Perlis N, et al.
J Clin Oncol
. 2024 Jul;
42(32):3806-3816.
PMID: 39038251
Purpose: Asian, Black, and Hispanic men are underrepresented in prostate cancer (PCa) clinical trials. Few novel prostate cancer biomarkers have been validated in diverse cohorts. We aimed to determine if...
5.
Plym A, Zhang Y, Stopsack K, Ugalde-Morales E, Seibert T, Conti D, et al.
JAMA Netw Open
. 2024 Jul;
7(7):e2420034.
PMID: 38958976
Importance: Prostate cancer, a leading cause of cancer death among men, urgently requires new prevention strategies, which may involve targeting men with an underlying genetic susceptibility. Objective: To explore differences...
6.
Rostami S, Rounge T, Pestarino L, Lyle R, Fortner R, Haaland O, et al.
Int J Cancer
. 2024 May;
155(5):946-956.
PMID: 38733362
Endometrial cancer (EC) is one of the most common female cancers and there is currently no routine screening strategy for early detection. An altered abundance of circulating microRNAs (miRNAs) and...
7.
Wang A, Shen J, Rodriguez A, Saunders E, Chen F, Janivara R, et al.
Nat Genet
. 2023 Nov;
55(12):2065-2074.
PMID: 37945903
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry...
8.
Darst B, Saunders E, Dadaev T, Sheng X, Wan P, Pooler L, et al.
JAMA Oncol
. 2023 Sep;
9(11):1514-1524.
PMID: 37733366
Importance: Germline gene panel testing is recommended for men with advanced prostate cancer (PCa) or a family history of cancer. While evidence is limited for some genes currently included in...
9.
Janson C, Wiklund F, Telg G, Stratelis G, Sandelowsky H
ERJ Open Res
. 2023 Jun;
9(3).
PMID: 37342089
Background: Short-acting β-agonist (SABA) overuse has been associated with an increased risk of exacerbations in asthma; however, less is known about SABA use in COPD. Our aim was to describe...
10.
Darst B, Shen J, Madduri R, Rodriguez A, Xiao Y, Sheng X, et al.
Am J Hum Genet
. 2023 Jun;
110(7):1200-1206.
PMID: 37311464
Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several...