Molecular Therapy : the Journal of the American Society of Gene Therapy
Overview
Molecular Therapy is a prestigious scientific journal published by the American Society of Gene Therapy. It focuses on cutting-edge research in the field of gene therapy, exploring the use of molecular tools to treat genetic disorders, cancer, and other diseases. With a multidisciplinary approach, the journal provides a platform for scientists to share their findings, advancements, and clinical trials, fostering the development of innovative therapeutic strategies.
Details
Details
Abbr.
Mol Ther
Publisher
Cell Press
Start
2000
End
Continuing
Frequency
Monthly
p-ISSN
1525-0016
e-ISSN
1525-0024
Country
United States
Language
English
Specialties
Pharmacology
Molecular Biology
Molecular Biology
Metrics
Metrics
h-index / Ranks: 637
209
SJR / Ranks: 408
3736
CiteScore / Ranks: 450
17.90
JIF / Ranks: 313
12.4
Recent Articles
1.
Papp T, Zeng J, Shahnawaz H, Akyianu A, Breda L, Yadegari A, et al.
Mol Ther
. 2025 Mar;
PMID: 40087866
mRNA-based therapeutics delivered via lipid nanoparticles (LNP-mRNA) hold great promise for treating diverse diseases. However, further improvements are needed to refine outcomes in non-vaccine, extrahepatic applications, such as minimizing the...
2.
Dreyzin A, Shao L, Cai Y, Lee Han K, Prochazkova M, Gertz M, et al.
Mol Ther
. 2025 Mar;
PMID: 40087865
Although CAR T-cell therapy is increasingly used to treat relapsed B-cell acute lymphoblastic leukemia (ALL), 20-30% of patients do not respond, and few clinical predictors of response have been established,...
3.
Ball J, Bradley A, Le A, Tisdale J, Uchida N
Mol Ther
. 2025 Mar;
PMID: 40083162
Sickle cell disease (SCD) is a single-gene disorder caused by a point mutation of the β-globin gene, resulting in hemolytic anemia, acute pain, multiorgan damage, and early mortality. Hydroxyurea is...
4.
Mallick R, Montaser A, Komi H, Juusola G, Tirronen A, Gurzeler E, et al.
Mol Ther
. 2025 Mar;
PMID: 40083161
Vascular endothelial growth factor B186 (VEGF-B186), a ligand for VEGF receptor 1 (VEGFR1) and neuropilin (NRP), promotes vascular growth in healthy and ischemic myocardium. However, the mechanisms and signaling of...
5.
Osborn M, Panda S, Reineke T, Tolar J, Nystrom A
Mol Ther
. 2025 Mar;
PMID: 40077969
The skin is the largest organ of the body and forms and serves as the barrier for preventing external material from accessing and damaging internal organs. As the outward interface...
6.
Patel K, Tariveranmoshabad M, Kadu S, Shobaki N, June C
Mol Ther
. 2025 Mar;
PMID: 40070120
Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer immunotherapy in the 21 century, providing innovative solutions and life-saving therapies for previously untreatable diseases. This approach has shown remarkable success...
7.
Yang S, Wang G, Chen J, Zhang W, Wu J, Liu W, et al.
Mol Ther
. 2025 Mar;
PMID: 40057828
Multiple myeloma (MM) relapse still occurs after a durable response to anti-BCMA chimeric antigen receptor-engineered T (CAR-T) cell therapy with less-defined factors. Herein, we investigated a CAR-T-exposed MM patient who...
8.
Zen R, Tsuji S, Tomoko M, Maeda T, Urushitani M, Murakami T, et al.
Mol Ther
. 2025 Mar;
PMID: 40057827
Neonatal hypoxic-ischemic encephalopathy is aggravated by intracerebral inflammation. As pro-inflammatory microglia in the brain become activated in this condition, we aimed to establish a novel peptide therapy for neonatal hypoxic-ischemic...
9.
Doshi B, Markmann C, Novak N, Rojas S, Davidson R, Chau J, et al.
Mol Ther
. 2025 Mar;
PMID: 40057826
Neutralizing antibodies (NAb) against adeno-associated virus (AAV) represent a significant obstacle to the efficacy of systemic recombinant AAV vector administration or re-administration. While there are some promising preclinical immunomodulation strategies...
10.
Begley S, ORourke D, Binder Z
Mol Ther
. 2025 Mar;
PMID: 40057825
Glioblastoma (GBM) is an aggressive primary brain tumor with a poor prognosis and few effective treatment options. Focus has shifted towards using immunotherapies, such as chimeric antigen receptor (CAR) T...