Alan Melcher
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Explore the profile of Alan Melcher including associated specialties, affiliations and a list of published articles.
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124
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3473
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Recent Articles
1.
Nguyen V, Namba H, Porter H, Shlyueva D, Lopez E, Melcher A, et al.
Blood
. 2025 Feb;
PMID: 40009485
Despite the approval of several new treatments for patients with B-cell lymphoma, there is still a large unmet need. Diffuse large B-cell lymphoma (DLBCL) and Follicular lymphoma (FLs) are the...
2.
Vile R, Pulido J, Chen A, Kendall B, Tonne J, Metko M, et al.
Res Sq
. 2024 Nov;
PMID: 39606441
T cell immune tolerance is established in part through the activity of the Auto-immune Regulator (AIRE) transcription factor in the medullary Thymic Epithelial Cells (mTEC) of the thymus. AIRE induces...
3.
Giangreco G, Rullan A, Naito Y, Biswas D, Liu Y, Hooper S, et al.
iScience
. 2024 Sep;
27(9):110635.
PMID: 39262776
Interactions between cells in the tumor microenvironment (TME) shape cancer progression and patient prognosis. To gain insights into how the TME influences cancer outcomes, we derive gene expression signatures indicative...
4.
Armstrong E, Chiu M, Foo S, Appleton L, Nenclares P, Patrikeev A, et al.
J Immunother Cancer
. 2024 Jul;
12(7).
PMID: 39060020
Background: Over the past decade, cancer immunotherapies have revolutionized the treatment of melanoma; however, responses vary across patient populations. Recently, baseline tumor size has been identified as an independent prognostic...
5.
Webb M, Sangsuwannukul T, van Vloten J, Evgin L, Kendall B, Tonne J, et al.
Nat Commun
. 2024 Jun;
15(1):5442.
PMID: 38937436
Although patients benefit from immune checkpoint inhibition (ICI) therapy in a broad variety of tumors, resistance may arise from immune suppressive tumor microenvironments (TME), which is particularly true of hepatocellular...
6.
Jimenez-Labaig P, Rullan A, Brana I, Hernando-Calvo A, Moreno V, Doger B, et al.
Cancer Treat Rev
. 2024 May;
127:102746.
PMID: 38696902
Background: Head and neck squamous cell carcinoma (HNSCC) presents an ideal scenario for intratumoral therapies (IT), due to its local recurrence pattern and frequent superficial extension. IT therapies aim to...
7.
Yoneyama M, Zormpas-Petridis K, Robinson R, Sobhani F, Provenzano E, Steel H, et al.
Int J Radiat Oncol Biol Phys
. 2024 Apr;
120(3):862-874.
PMID: 38677525
Purpose: Tumor-infiltrating lymphocytes (TILs) have prognostic significance in several cancers, including breast cancer. Despite interest in combining radiation therapy with immunotherapy, little is known about the effect of radiation therapy...
8.
Baker A, Nageswaran G, Nenclares P, Ronel T, Smith K, Kimberley C, et al.
Cancer Res
. 2024 Mar;
84(10):1560-1569.
PMID: 38479434
Significance: FUME-TCRseq is a TCR sequencing methodology that supports sensitive and spatially resolved detection of TCR clones in archival clinical specimens, which can facilitate longitudinal tracking of immune responses through...
9.
Hristova D, Oliveira M, Wagner E, Melcher A, Harrington K, Belot A, et al.
iScience
. 2024 Jan;
27(1):108760.
PMID: 38269102
To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The mechanisms by which intracellular DNA and...
10.
Nenclares P, Larkeryd A, Manodoro F, Lee J, Lalondrelle S, Gilbert D, et al.
Front Oncol
. 2024 Jan;
13():1296948.
PMID: 38234396
Background: The effect of chemoradiation on the anti-cancer immune response is being increasingly acknowledged; however, its clinical implications in treatment responses are yet to be fully understood. Human papillomavirus (HPV)-driven...