Gianfranco Battistuzzi
Overview
Explore the profile of Gianfranco Battistuzzi including associated specialties, affiliations and a list of published articles.
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25
Citations
165
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Recent Articles
1.
DAlessio F, Lione L, Salvatori E, Bucci F, Muzi A, Roscilli G, et al.
Vaccines (Basel)
. 2023 Mar;
11(3).
PMID: 36992261
DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for efficacy,...
2.
Milazzo F, Chaves-Sanjuan A, Minenkova O, Santapaola D, Anastasi A, Battistuzzi G, et al.
Mol Ther
. 2022 Sep;
31(2):362-373.
PMID: 36114671
The uneven worldwide vaccination coverage against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and emergence of variants escaping immunity call for broadly effective and easily deployable therapeutic agents. We have...
3.
Minenkova O, Santapaola D, Milazzo F, Anastasi A, Battistuzzi G, Chiapparino C, et al.
Mol Ther
. 2022 Feb;
30(5):1979-1993.
PMID: 35167974
As of December 2021, coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global emergency, and novel therapeutics are urgently needed. Here we...
4.
Cianferotti C, Faltoni V, Cini E, Ermini E, Migliorini F, Petricci E, et al.
Chem Commun (Camb)
. 2021 Jan;
57(7):867-870.
PMID: 33433550
Antitumor hydroxamates SAHA and Dacinostat have been linked to cetuximab and trastuzumab through a non-cleavable linker based on the p-mercaptobenzyl alcohol structure. These antibody drug conjugates (ADCs) were able to...
5.
Pala D, Scalvini L, Elisi G, Lodola A, Mor M, Spadoni G, et al.
J Enzyme Inhib Med Chem
. 2020 Sep;
35(1):1685-1696.
PMID: 32907434
Heparanase is a validated target in cancer therapy and a potential target for several inflammatory pathologies. A ligand-based virtual screening of commercial libraries was performed to expand the chemical space...
6.
Giannini G, Battistuzzi G, Rivara S
Adv Exp Med Biol
. 2020 Apr;
1221:567-603.
PMID: 32274727
Despite the enormous progress made in recent years with antibodies, vaccines, antisense oligonucleotides, etc., the so-called "biological" approaches for tackling the control of various diseases, medicinal chemistry remains a bulwark...
7.
Milazzo F, Vesci L, Anastasi A, Chiapparino C, Rosi A, Giannini G, et al.
Front Oncol
. 2020 Feb;
9:1534.
PMID: 32039017
Targeted therapy using monoclonal antibodies conjugated to toxins is gaining space in the treatment of cancer. Here, we report the anti-tumor effect of a new antibody drug conjugate (ADC) delivering...
8.
Giannini G, Milazzo F, Battistuzzi G, Rosi A, Anastasi A, Petronzelli F, et al.
Bioorg Med Chem
. 2019 Jun;
27(15):3248-3253.
PMID: 31208798
Tenatumomab is an anti-tenascin murine monoclonal antibody previously used in clinical trials for delivering radionuclides to tumors by both pre-targeting (biotinylated Tenatumomab within PAGRIT) and direct Iodine labeling approaches. Here...
9.
Messore A, Madia V, Pescatori L, Saccoliti F, Tudino V, De Leo A, et al.
J Med Chem
. 2018 Nov;
61(23):10834-10859.
PMID: 30412404
Heparanase is the only mammalian endo-β-d-glucuronidase involved in a variety of major diseases. The up-regulation of heparanase expression increases tumor size, angiogenesis, and metastasis, representing a validated target in the...
10.
Cini E, Faltoni V, Petricci E, Taddei M, Salvini L, Giannini G, et al.
Chem Sci
. 2018 Oct;
9(31):6490-6496.
PMID: 30288233
We describe here two novel antibody-drug conjugates loaded with the HDAC inhibitor ST7612AA1 (IC equal to 0.07 μM on NCI-H460 cells), a thiol-based molecule with a moderate toxicity . Two...