Gianfranco Battistuzzi
Overview
Explore the profile of Gianfranco Battistuzzi including associated specialties, affiliations and a list of published articles.
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25
Citations
165
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Recent Articles
11.
Madia V, Messore A, Pescatori L, Saccoliti F, Tudino V, De Leo A, et al.
J Med Chem
. 2018 Jul;
61(15):6918-6936.
PMID: 30010344
Heparanase is the sole mammalian enzyme capable of cleaving glycosaminoglycan heparan sulfate side chains of heparan sulfate proteoglycans. Its altered activity is intimately associated with tumor growth, angiogenesis, and metastasis....
12.
Battistuzzi G, Giannini G
Curr Bioact Compd
. 2016 Dec;
12(4):282-288.
PMID: 27917100
Abstract Background: In the expanding field of anticancer drugs, HDAC inhibitors are playing an increasingly important role. To date, four/five HDAC inhibitors have been approved by FDA. All these compounds...
13.
Giannini G, Battistuzzi G, Vignola D
Bioorg Med Chem Lett
. 2015 Jan;
25(3):459-61.
PMID: 25563890
Recent studies have highlighted a key role in regulating gene transcription, in both eukaryotes and prokaryotes, by enzymes that control the acetylation and deacetylation of histones. In particular, inhibitors of...
14.
Giannini G, Battistuzzi G
Bioorg Med Chem Lett
. 2014 Dec;
25(3):462-5.
PMID: 25547934
A set of compounds, previously selected as potent Hsp90α inhibitors, has been studied on a panel of human parasites. 5-Aryl-3,4-isoxazolediamide derivatives (1) were active against two protozoa, Trypanosoma brucei rhodesiense...
15.
Giannini G, Vesci L, Battistuzzi G, Vignola D, Milazzo F, Guglielmi M, et al.
J Med Chem
. 2014 Sep;
57(20):8358-77.
PMID: 25233084
A systematic study of medicinal chemistry aimed at identifying a new generation of HDAC inhibitors, through the introduction of a thiol zinc-binding group (ZBG) and of an amide-lactam in the...
16.
Baruchello R, Simoni D, Marchetti P, Rondanin R, Mangiola S, Costantini C, et al.
Eur J Med Chem
. 2014 Feb;
76:53-60.
PMID: 24565573
Hsp90 is considered an interesting therapeutic target for anticancer drug development. Here we describe a new class of 4,5,6,7-tetrahydro-isoxazolo-[4,5-c]-pyridine compounds. A small library of derivatives has been synthesized and investigated....
17.
Giannini G, Battistuzzi G, Vesci L, Milazzo F, De Paolis F, Barbarino M, et al.
Bioorg Med Chem Lett
. 2014 Jan;
24(2):462-6.
PMID: 24388690
Poly(ADP-ribose)polymerase-I (PARP-1) enzyme is involved in maintaining DNA integrity and programmed cell death. A virtual screening of commercial libraries led to the identification of five novel scaffolds with inhibitory profile...
18.
Taddei M, Cini E, Giannotti L, Giannini G, Battistuzzi G, Vignola D, et al.
Bioorg Med Chem Lett
. 2013 Dec;
24(1):61-4.
PMID: 24345446
A series of SAHA-like molecules were prepared introducing different lactam-carboxyamides in position 7 of the suberoylanilide skeleton. The activity against different HDAC isoforms was tested and the data compared with...
19.
Giannini G, Brunetti T, Battistuzzi G, Alloatti D, Quattrociocchi G, Cima M, et al.
Bioorg Med Chem
. 2012 Feb;
20(7):2405-15.
PMID: 22365912
Adarotene belongs to the so-called class of atypical retinoids. The presence of the phenolic hydroxyl group on Adarotene structure allows a rapid O-glucuronidation as a major mechanism of elimination of...
20.
Auzzas L, Larsson A, Matera R, Baraldi A, Deschenes-Simard B, Giannini G, et al.
J Med Chem
. 2010 Nov;
53(23):8387-99.
PMID: 21073160
Nonpeptidic chiral macrocycles were designed on the basis of an analogue of suberoylanilide hydroxamic acid (2) (SAHA, vorinostat) and evaluated against 11 histone deacetylase (HDAC) isoforms. The identification of critical...