Walter Cabri
Overview
Explore the profile of Walter Cabri including associated specialties, affiliations and a list of published articles.
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Articles
72
Citations
436
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Recent Articles
1.
Pisano R, Arsiccio A, Collins V, King P, Macis M, Cabri W, et al.
Mol Pharm
. 2024 Jul;
21(8):3815-3823.
PMID: 39046445
Peptide aggregation poses a significant challenge in biopharmaceutical development and neurodegenerative diseases. This study combines computational simulations and experimental validation to uncover the underlying mechanisms and countermeasures for the aggregation...
2.
Mazzoccanti G, Manetto S, Bassan M, Macis M, Cabri W, Ciogli A, et al.
Eur J Pharm Sci
. 2023 Dec;
193:106682.
PMID: 38142950
The biopharmaceutical industry faces the challenge of efficiently characterising impurity profiles of therapeutical peptides, also due to their complex polar and ionisable attributes. This research explores the potential of advanced...
3.
Bozza D, De Luca C, Felletti S, Spedicato M, Presini F, Giovannini P, et al.
J Chromatogr A
. 2023 Nov;
1713:464530.
PMID: 38035518
Preparative liquid chromatography in reversed phase conditions (RPLC) is the most common approach adopted in the downstream processing for the purification of therapeutic peptides at industrial level. Due to the...
4.
Felletti S, Spedicato M, Bozza D, De Luca C, Presini F, Giovannini P, et al.
J Chromatogr A
. 2023 Nov;
1712:464477.
PMID: 37944433
Nowadays, environmental problems are drawing the attention of governments and international organisations, which are therefore encouraging the transition to green industrial processes and approaches. In this context, chemists can help...
5.
Mattellone A, Corbisiero D, Cantelmi P, Martelli G, Palladino C, Tolomelli A, et al.
Molecules
. 2023 Oct;
28(20).
PMID: 37894662
The growing applications of peptide-based therapeutics require the development of efficient protocols from the perspective of an industrial scale-up. T3P (cyclic propylphosphonic anhydride) promotes amidation in the solution-phase through a...
6.
Ferrazzano L, Tolomelli A, Guryanov I, Macis M, Abel U, Ricci A, et al.
Pharmacol Res Perspect
. 2023 Jul;
11(4):e01117.
PMID: 37455491
One of the main objectives of peptide drug design is the improvement of peptide pharmacokinetics with maintaining biological activity, which can be achieved by the complex modifications of the primary...
7.
Marassi V, Macis M, Giordani S, Ferrazzano L, Tolomelli A, Roda B, et al.
Molecules
. 2022 Sep;
27(17).
PMID: 36080254
Aggregation is among the most critical parameters affecting the pharmacological and safety profile of peptide Active Pharmaceutical Ingredients (APIs). For this reason, it is of utmost importance to define the...
8.
Corbisiero D, Fantoni T, Ferrazzano L, Martelli G, Cantelmi P, Mattellone A, et al.
ACS Omega
. 2022 Aug;
7(30):26919-26927.
PMID: 35936453
The enantioselective 1,3-dipolar cycloaddition of nitrones and arylpropionaldehydes to generate highly functionalized scaffolds for application in drug discovery was herein investigated. The use of a second-generation MacMillan catalyst as hydrochloride...
9.
Orlandin A, Guryanov I, Ferrazzano L, Biondi B, Biscaglia F, Storti C, et al.
Molecules
. 2022 Jul;
27(13).
PMID: 35807480
The suppression of side reactions is one of the most important objectives in peptide synthesis, where highly reactive compounds are involved. Recently, the violuric acid derivative Oxyma-B was introduced into...
10.
Mazzoccanti G, Manetto S, Bassan M, Foschini A, Orlandin A, Ricci A, et al.
RSC Adv
. 2022 May;
10(21):12604-12610.
PMID: 35497586
The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in...