Journal of Enzyme Inhibition and Medicinal Chemistry
Overview
The Journal of Enzyme Inhibition and Medicinal Chemistry is a peer-reviewed scientific journal that focuses on the study of enzyme inhibition and its applications in medicinal chemistry. It publishes original research articles, reviews, and perspectives covering various aspects of enzyme inhibition, including drug discovery, design, and development. The journal serves as a platform for researchers and scientists to share their findings and advancements in this field, contributing to the understanding and development of novel therapeutic strategies.
Details
Details
Abbr.
J Enzyme Inhib Med Chem
Start
2002
End
Continuing
Frequency
Bimonthly
p-ISSN
1475-6366
e-ISSN
1475-6374
Country
United Kingdom
Language
English
Specialty
Biochemistry
Metrics
Metrics
h-index / Ranks: 3550
92
SJR / Ranks: 4155
949
CiteScore / Ranks: 1542
9.70
JIF / Ranks: 1276
5.6
Recent Articles
1.
Xu Z, Guan L, Wang Y, Niu M, Ruan Y, Xu C, et al.
J Enzyme Inhib Med Chem
. 2025 Mar;
40(1):2467798.
PMID: 40052927
PLK1 is essential for cell cycle regulation and proliferation, and its elevated expression in prostate cancer is associated with high tumour grade. Therefore, PLK1 inhibition is considered a promising strategy...
2.
El-Wakil M, Ghazala R, El-Dershaby H, Drozdowska D, Wrobel-Talalaj A, Parzych C, et al.
J Enzyme Inhib Med Chem
. 2025 Mar;
40(1):2468353.
PMID: 40035286
In light of searching for new breast cancer therapies, DNA-targeted small molecules were rationally designed to simultaneously bind DNA and inhibit human dihydrofolate reductase (DHFR). Fourteen new arylidene-hydrazinyl-1,3-thiazoles () were...
3.
Lin C, Hsu J, Hsu Y, Fan K, Wu S, Lin M, et al.
J Enzyme Inhib Med Chem
. 2025 Feb;
40(1):2468355.
PMID: 40013582
The enigmatic histone deacetylase 6 (HDAC6) is one of a kind among its family. Recent reports revealed that HDAC6 CD1 exhibits E3 ligase activity. Inspired by these researches, we attempted...
4.
Pyrczak-Felczykowska A, Kaczorowska A, Gieldon A, Braczko A, Smolenski R, Antosiewicz J, et al.
J Enzyme Inhib Med Chem
. 2025 Feb;
40(1):2465575.
PMID: 40013402
The impact of the isoxazole derivative of usnic acid, (formerly known as 2b) on cancer and non-cancerous cell metabolism was investigated. significantly reduced the utilisation of most metabolic substrates that...
5.
Yang C, Chen L, Jiang Y, Sun D, Hu Y
J Enzyme Inhib Med Chem
. 2025 Feb;
40(1):2470310.
PMID: 40008549
Increasing the expression of ATP-binding cassette transporter A1 (ABCA1) can lower cellular cholesterol levels and prevent foam cell formation. In this study, a series of 5, 6-dihydro-8-isoquinolino[1, 2-]quinazolin-8-one derivatives were...
6.
Iacono R, Paragliola F, Strazzulli A, Moracci M
J Enzyme Inhib Med Chem
. 2025 Feb;
40(1):2468859.
PMID: 39995088
GH31 glycosidases are widespread across organisms, but remarkably, less than 1% of them have been biochemically characterised to date. Among them, human lysosomal acid α-glucosidase (GAA) stands out due to...
7.
Albassam H, Almutairi O, Alnasser M, Altowairqi F, Almutairi F, Alobid S
J Enzyme Inhib Med Chem
. 2025 Feb;
40(1):2468852.
PMID: 39992303
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, driving an urgent need for effective therapies. A promising avenue of research focuses on the PI3K/AKT/mTOR signalling pathway, which...
8.
Gafforov Y, Bekic S, Yarasheva M, Miskovic J, Zivanovic N, Chen J, et al.
J Enzyme Inhib Med Chem
. 2025 Feb;
40(1):2461185.
PMID: 39992291
This study investigates the mycochemical profile and biological activities of hydroethanolic (EtOH), chloroform (CHCl), and hot water (HO) extracts of from Uzbekistan. Antioxidant capacity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic...
9.
Lv X, Yang C, Li X, Liu Y, Yang Y, Jin T, et al.
J Enzyme Inhib Med Chem
. 2025 Feb;
40(1):2468853.
PMID: 39992186
Hearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing loss (SNHL) being a major concern. Linked to ototoxic medications, ageing, and noise exposure, SNHL...
10.
Xun Q, Zhang J, Feng L, Ma Y, Li Y, Shi X
J Enzyme Inhib Med Chem
. 2025 Feb;
40(1):2466846.
PMID: 39976249
Herein, a novel pyrrolo[2,3-]pyridine-based glycogen synthase kinase 3β (GSK-3β) inhibitor, , was rationally designed and synthesised to target Alzheimer's disease (AD). inhibited GSK-3β, with an IC of 0.35 ± 0.06 ...