Edward Darzynkiewicz
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Explore the profile of Edward Darzynkiewicz including associated specialties, affiliations and a list of published articles.
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120
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2387
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Recent Articles
21.
Niedzwiecka A, Nilsson P, Worch R, Stepinski J, Darzynkiewicz E, Virtanen A
Biochim Biophys Acta
. 2016 Jan;
1864(4):331-45.
PMID: 26772900
The mRNA 5' cap structure plays a pivotal role in coordination of eukaryotic translation and mRNA degradation. Poly(A)-specific ribonuclease (PARN) is a dimeric exoribonuclease that efficiently degrades mRNA 3' poly(A)...
22.
Ziemniak M, Kowalska J, Lukaszewicz M, Zuberek J, Wnek K, Darzynkiewicz E, et al.
Bioorg Med Chem
. 2015 Aug;
23(17):5369-81.
PMID: 26264844
The synthesis and biochemical properties of 17 new mRNA cap analogues are reported. Six of these nucleotides are m(7)GTP derivatives, whereas 11 are 'two headed' tetraphosphate dinucleotides based on a...
23.
Piecyk K, Niedzwiecka A, Ferenc-Mrozek A, Lukaszewicz M, Darzynkiewicz E, Jankowska-Anyszka M
Bioorg Med Chem
. 2015 Jun;
23(15):4660-4668.
PMID: 26118337
Snurportin 1 is an adaptor protein that mediates the active nuclear import of uridine-rich small nuclear RNAs (U snRNA) by the importin-β receptor pathway. Its cellular activity influences the overall...
24.
Piecyk K, Darzynkiewicz Z, Jankowska-Anyszka M, Ferenc-Mrozek A, Stepinski J, Darzynkiewicz E, et al.
Biochem Biophys Res Commun
. 2015 Jun;
464(1):89-93.
PMID: 26049109
Scavenger decapping enzymes (DcpS) are involved in eukaryotic mRNA degradation process. They catalyze the cleavage of residual cap structure m(7)GpppN and/or short capped oligonucleotides resulting from exosom-mediated the 3' to...
25.
Kubacka D, Miguel R, Minshall N, Darzynkiewicz E, Standart N, Zuberek J
J Mol Biol
. 2014 Dec;
427(2):387-405.
PMID: 25463438
eIF4E1b, closely related to the canonical translation initiation factor 4E (eIF4E1a), cap-binding protein is highly expressed in mouse, Xenopus and zebrafish oocytes. We have previously characterized eIF4E1b as a component...
26.
Kropiwnicka A, Kuchta K, Lukaszewicz M, Kowalska J, Jemielity J, Ginalski K, et al.
Biochem Biophys Res Commun
. 2014 Dec;
456(1):47-52.
PMID: 25446076
The assembly of the ribosome on majority of eukaryotic mRNAs is initiated by the recruitment of eIF4E protein to the mRNA 5' end cap structure. Flowering plants use two eIF4E...
27.
Zytek M, Kowalska J, Lukaszewicz M, Wojtczak B, Zuberek J, Ferenc-Mrozek A, et al.
Org Biomol Chem
. 2014 Oct;
12(45):9184-99.
PMID: 25296894
A trimethylguanosine (TMG) cap is present at the 5' end of several small nuclear and nucleolar RNAs. Recently, it has been reported that the TMG cap is a potential nuclear...
28.
Piecyk K, Lukaszewicz M, Darzynkiewicz E, Jankowska-Anyszka M
RNA
. 2014 Aug;
20(10):1539-47.
PMID: 25150228
Synthetic analogs of the 5' end of mRNA (cap structure) are widely used in molecular studies on mechanisms of cellular processes such as translation, intracellular transport, splicing, and turnover. The...
29.
Kowalska J, Wypijewska Del Nogal A, Darzynkiewicz Z, Buck J, Nicola C, Kuhn A, et al.
Nucleic Acids Res
. 2014 Aug;
42(16):10245-64.
PMID: 25150148
Modified mRNA cap analogs aid in the study of mRNA-related processes and may enable creation of novel therapeutic interventions. We report the synthesis and properties of 11 dinucleotide cap analogs...
30.
Freire E, Vashisht A, Malvezzi A, Zuberek J, Langousis G, Saada E, et al.
RNA
. 2014 Jun;
20(8):1272-86.
PMID: 24962368
Members of the eIF4E mRNA cap-binding family are involved in translation and the modulation of transcript availability in other systems as part of a three-component complex including eIF4G and eIF4A....