Edward Darzynkiewicz
Overview
Explore the profile of Edward Darzynkiewicz including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
120
Citations
2387
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Dobiezynska A, Miszkiewicz J, Darzynkiewicz Z, Tyras M, Stankiewicz-Drogon A, Trylska J, et al.
Biochem Biophys Res Commun
. 2020 Sep;
533(3):391-396.
PMID: 32962861
The interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of RNA-binding proteins that are very highly expressed during antiviral response of immune system. IFIT proteins recognize and tightly bind...
12.
Ferenc-Mrozek A, Bojarska E, Stepinski J, Darzynkiewicz E, Lukaszewicz M
ACS Omega
. 2020 May;
5(19):10759-10766.
PMID: 32455195
Decapping scavenger enzymes (DcpSs) are important players in mRNA degradation machinery and conserved in eukaryotes. Importantly, human DcpS is the recognized target for spinal muscular atrophy (SMA) and acute myeloid...
13.
Galloway A, Atrih A, Grzela R, Darzynkiewicz E, Ferguson M, Cowling V
Open Biol
. 2020 Feb;
10(2):190306.
PMID: 32097574
Eukaryotic messenger RNA (mRNA) is modified by the addition of an inverted guanosine cap to the 5' triphosphate. The cap guanosine and initial transcribed nucleotides are further methylated by a...
14.
Miedziak B, Dobiezynska A, Darzynkiewicz Z, Bartkowska J, Miszkiewicz J, Kowalska J, et al.
RNA
. 2019 Oct;
26(1):58-68.
PMID: 31658992
In response to foreign RNA, cellular antiviral mechanisms stimulate high expression of interferon-induced proteins with tetratricopeptide repeats (IFITs). Two members of the IFIT protein family, IFIT1 and IFIT5, are capable...
15.
Pietrow P, Ferenc-Mrozek A, Piecyk K, Bojarska E, Darzynkiewicz E, Jankowska-Anyszka M
ACS Omega
. 2019 Oct;
4(17):17576-17580.
PMID: 31656932
mRNA degradation is a key mechanism of gene expression regulation. In the 3' → 5' decay pathway, mRNA is degraded by the exosome complex and the resulting cap dinucleotide or...
16.
Kocmik I, Piecyk K, Rudzinska M, Niedzwiecka A, Darzynkiewicz E, Grzela R, et al.
Cell Cycle
. 2018 Jun;
17(13):1624-1636.
PMID: 29954234
Nowadays gene manipulation techniques ("DNA therapy") undergo progressive development and become widely used in industry and medicine. Since new advances in mRNA technologies are capable for obtaining particles with increased...
17.
Grzela R, Nasilowska K, Lukaszewicz M, Tyras M, Stepinski J, Jankowska-Anyszka M, et al.
RNA
. 2018 Feb;
24(5):633-642.
PMID: 29483298
Human Nudt16 (hNudt16) is a member of the Nudix family of hydrolases, comprising enzymes catabolizing various substrates including canonical (d)NTPs, oxidized (d)NTPs, nonnucleoside polyphosphates, and capped mRNAs. Decapping activity of...
18.
Rydzik A, Warminski M, Sikorski P, Baranowski M, Walczak S, Kowalska J, et al.
Nucleic Acids Res
. 2017 Jul;
45(15):8661-8675.
PMID: 28666355
Analogues of the mRNA 5'-cap are useful tools for studying mRNA translation and degradation, with emerging potential applications in novel therapeutic interventions including gene therapy. We report the synthesis of...
19.
Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA
Warminski M, Sikorski P, Warminska Z, Lukaszewicz M, Kropiwnicka A, Zuberek J, et al.
Bioconjug Chem
. 2017 Jun;
28(7):1978-1992.
PMID: 28613834
mRNA is a template for protein biosynthesis, and consequently mRNA transport, translation, and turnover are key elements in the overall regulation of gene expression. Along with growing interest in the...
20.
Strenkowska M, Grzela R, Majewski M, Wnek K, Kowalska J, Lukaszewicz M, et al.
Nucleic Acids Res
. 2016 Dec;
44(20):9578-9590.
PMID: 27903882
Along with a growing interest in mRNA-based gene therapies, efforts are increasingly focused on reaching the full translational potential of mRNA, as a major obstacle for in vivo applications is...