David P Fairlie
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Explore the profile of David P Fairlie including associated specialties, affiliations and a list of published articles.
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321
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9988
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Recent Articles
1.
Boulouis C, Mouchtaridi E, Muller T, Mak J, Fairlie D, Bergman P, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(6):e2414230122.
PMID: 39903121
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that mediate rapid antimicrobial immune responses to antigens derived from microbial riboflavin pathway metabolites presented by the evolutionarily conserved MR1 molecules....
2.
Shah H, Fairlie D, Lim J
J Pharmacol Exp Ther
. 2025 Feb;
392(1):100016.
PMID: 39892996
Cancers affecting women, such as breast, uterine, ovarian, endometrial, and cervical cancers, have become increasingly prevalent. The growing incidence and death rates associated with these cancers warrant the development of...
3.
Awad W, Mayall J, Xu W, Johansen M, Patton T, Lim X, et al.
J Exp Med
. 2025 Jan;
222(2.
PMID: 39820322
Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function....
4.
Wang H, Souter M, de Lima Moreira M, Li S, Zhou Y, Nelson A, et al.
Sci Immunol
. 2024 Dec;
9(102):eadp9841.
PMID: 39642244
Mucosal-associated invariant T (MAIT) cells are known for their rapid effector functions and antibacterial immune protection. Here, we define the plasticity of interferon-γ (IFN-γ)-producing MAIT1 and interleukin-17A (IL-17A)-producing MAIT17 cell...
5.
McInerney M, Awad W, Souter M, Kang Y, Wang C, Chan Yew Poa K, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2414792121.
PMID: 39589872
The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal-associated invariant T (MAIT) cells. MR1 can also present other metabolites to activate MR1-restricted...
6.
Xu C, Obers A, Qin M, Brandli A, Wong J, Huang X, et al.
J Exp Med
. 2024 Nov;
221(12).
PMID: 39560665
Unconventional T cells, including mucosal-associated invariant T (MAIT), natural killer T (NKT), and gamma-delta T (γδT) cells, comprise distinct T-bet+, IFN-γ+ and RORγt+, IL-17+ subsets which play differential roles in...
7.
Wang Y, Curson J, Ramnath D, Das Gupta K, Reid R, Karunakaran D, et al.
Biochem J
. 2024 Oct;
481(21):1569-1584.
PMID: 39373581
Histone deacetylase 7 (HDAC7) is a member of the class IIa family of classical HDACs with important roles in cell development, differentiation, and activation, including in macrophages and other innate...
8.
Kammann T, Cai C, Sekine T, Mouchtaridi E, Boulouis C, Nilsen V, et al.
Sci Immunol
. 2024 Sep;
9(99):eadn2362.
PMID: 39241054
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules. We explored the human MAIT cell compartment across organ...
9.
Poon E, Liu L, Wu K, Lim J, Sweet M, Lohman R, et al.
Br J Pharmacol
. 2024 Sep;
181(23):4804-4821.
PMID: 39223784
Background And Purpose: Most inhibitors of histone deacetylases (HDACs) are not selective and are cytotoxic. Some have anti-inflammatory activity in disease models, but cytotoxicity prevents long-term uses in non-fatal diseases....
10.
Purohit S, Stern L, Corbett A, Mak J, Fairlie D, Slobedman B, et al.
PLoS Pathog
. 2024 Aug;
20(8):e1012372.
PMID: 39110717
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that respond to riboflavin biosynthesis and cytokines through TCR-dependent and -independent pathways, respectively. MAIT cell activation plays an immunoprotective role against...