Timothy A Hill
Overview
Explore the profile of Timothy A Hill including associated specialties, affiliations and a list of published articles.
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40
Citations
764
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Recent Articles
1.
Wu Z, Shen S, Mizikovsky D, Cao Y, Naval-Sanchez M, Tan S, et al.
Dev Cell
. 2024 Feb;
59(6):705-722.e8.
PMID: 38354738
Wnt signaling is a critical determinant of cell lineage development. This study used Wnt dose-dependent induction programs to gain insights into molecular regulation of stem cell differentiation. We performed single-cell...
2.
Shah H, Hill T, Lim J, Fairlie D
J Cell Commun Signal
. 2023 Nov;
17(4):1293-1307.
PMID: 37991681
Drug resistance represents a major problem in cancer treatment. Doxorubicin (adriamycin) is an injectable DNA intercalating drug that halts cancer cell growth by inhibiting topoisomerase 2, but its long-term effectiveness...
3.
Rollo R, Mori G, Hill T, Hillemann D, Niemann S, Homolka S, et al.
Microbiol Spectr
. 2023 Jun;
11(4):e0046523.
PMID: 37289062
Shorter and more effective treatment regimens as well as new drugs are urgent priorities for reducing the immense global burden of tuberculosis (TB). As treatment of TB currently requires multiple...
4.
Wu K, Condon N, Hill T, Reid R, Fairlie D, Lim J
J Innate Immun
. 2023 Mar;
15(1):468-484.
PMID: 36882040
Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted...
5.
Wu C, Hoang H, Hill T, Lim J, Kok W, Akondi K, et al.
Chem Commun (Camb)
. 2022 Oct;
58(89):12475-12478.
PMID: 36274265
An alpha helical turn can be reproduced in a cyclic pentapeptide if the first and fifth amino acid sidechains are correctly joined. Here structural studies (CD, NMR, ) reveal why...
6.
Wang P, Hill T, Mitchell J, Fitzsimmons R, Xu W, Loh Z, et al.
J Med Chem
. 2022 Aug;
65(17):11759-11775.
PMID: 35984914
Glucagon-like peptide-1 (GLP-1) lowers blood glucose by inducing insulin but also has other poorly understood properties. Here, we show that hydroxy amino acids (Thr11, Ser14, Ser17, Ser18) in GLP-1(7-36) act...
7.
Chen K, Guo Q, Hill T, Cui Y, Kendall A, Yang Z, et al.
Sci Adv
. 2021 Dec;
7(49):eabg4007.
PMID: 34851660
The retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane trafficking and signaling. Mutation of the retromer subunit Vps35 causes late-onset Parkinson’s disease, while viral and bacterial pathogens can hijack the...
8.
Hoang H, Hill T, Fairlie D
Angew Chem Int Ed Engl
. 2020 Nov;
60(15):8385-8390.
PMID: 33185961
N- or C-methylation in natural and synthetic cyclic peptides can increase membrane permeability, but it remains unclear why this happens in some cases but not others. Here we compare three-dimensional...
9.
Hoang H, Hill T, Ruiz-Gomez G, Diness F, Mason J, Wu C, et al.
Chem Sci
. 2020 Feb;
10(45):10595-10600.
PMID: 32110345
Protein-protein interactions involve hotspots as small as 4 sequential amino acids. Corresponding tetrapeptides have no structure in water. Here we report linking side chains of amino acids X and Z...
10.
Lohman R, Nielsen D, Kok W, Hoang H, Hill T, Fairlie D
Chem Commun (Camb)
. 2019 Oct;
55(89):13362-13365.
PMID: 31631195
Rule-of-five parameters and membrane permeabilities have been routinely used to guide development of orally bioavailabile drugs. Here we compare enantiomeric pairs of cyclic hexapeptides with identical rule-of-five parameters and membrane...