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British Journal of Pharmacology

The British Journal of Pharmacology is a renowned scientific journal that publishes cutting-edge research in the field of pharmacology. It covers a wide range of topics including drug discovery, mechanisms of drug action, clinical pharmacology, and therapeutics. With a strong emphasis on rigorous scientific methodology, the journal serves as a valuable resource for researchers, clinicians, and pharmacologists worldwide.
Details
Abbr. Br J Pharmacol
Publisher Wiley
Start 1968
End Continuing
Frequency Twenty four no. a year
p-ISSN 0007-1188
e-ISSN 1476-5381
Country United Kingdom
Language English
Specialty Pharmacology
Metrics
h-index / Ranks: 400 244
SJR / Ranks: 1092 2119
CiteScore / Ranks: 593 15.30
JIF / Ranks: 805 7.3
Recent Articles
1.
Drug-likeness evaluation and inhibitory mechanism of the emodin derivative on cardiac fibrosis based on metastasis-associated protein 3
Liu H, Li R, Wang Z, Han W, Sun X, Dong X, et al.
Br J Pharmacol . 2025 Mar; PMID: 40083252
Background And Purpose: Emodin inhibits cardiac fibrosis through metastasis-associated protein 3 (MTA3), but its limited bioavailability hinders clinical application. To enhance emodin's clinical potential, a new derivative, emodin succinyl ethyl...
2.
Rescue of loss-of-function long QT syndrome-associated mutations in K7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S)
Hiniesto-Inigo I, Sridhar A, Louradour J, Cruz A, de la Cruz A, Lundholm S, et al.
Br J Pharmacol . 2025 Mar; PMID: 40083204
Background And Purpose: Congenital long QT syndrome (LQTS) involves genetic mutations affecting ion channels, leading to a prolonged QT interval and increased risk of potentially lethal ventricular arrhythmias. Mutations in...
3.
Systemic EP4 receptor agonist and Arginase-1 therapy in a murine model of chronic asthma and influenza virus-induced asthma exacerbation
Lange T, Brunn T, Vetter C, Bloch K, Vedder N, van Geffen C, et al.
Br J Pharmacol . 2025 Mar; PMID: 40070177
Background And Purpose: Myeloid-derived suppressor cells (MDSCs) play important roles in the pathogenesis of asthma. Recent studies demonstrate that their function can be modulated by different pharmacological approaches. In this...
4.
Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel
Karlsson E, Anden O, Fan C, Fourati Z, Haouz A, Zhuang Y, et al.
Br J Pharmacol . 2025 Mar; PMID: 40065647
Background And Purpose: Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) are critical for the action of neurotransmitters and many psychoactive drugs. However, details of their modulatory mechanisms remain unclear,...
5.
Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin
Li H, Chen C, Chen X, Liu J, Luo C, Chen H, et al.
Br J Pharmacol . 2025 Mar; PMID: 40065575
Background And Purpose: We previously showed that the iridoid glycoside extract of Lamiophlomis rotata (IGLR) induces M2 macrophage polarisation to accelerate wound healing. The potentially active compounds (quality markers) in...
6.
SEW2871 attenuates myocyte necroptosis in heart failure through inhibition of oxidative stress and inflammatory cytokines
Guo H, Tantai R, Yang B, Yang L, Ma Y, Zhao H, et al.
Br J Pharmacol . 2025 Mar; PMID: 40064624
Background And Purpose: Sphingosine-1-phosphate (S1P)/S1P receptor signalling exerts cardioprotective effects. However, the effect of the selective S1P receptor agonist SEW2871 on myocyte necroptosis in heart failure and the underlying mechanisms...
7.
Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1-mediated autophagy
Zou Y, Tao Z, Li P, Yang J, Xu Q, Xu X, et al.
Br J Pharmacol . 2025 Mar; PMID: 40052261
Background And Purpose: Subarachnoid haemorrhage (SAH) is an uncommon and severe subtype of stroke, but the availability of drugs for its treatment is limited. Enhanced autophagy is believed to attenuate...
8.
2-Hydroxyl hispolon reverses high glucose-induced endothelial progenitor cell dysfunction through the PI3K/Akt/eNOS and AMPK/HO-1 pathways
Wang T, Hou W, Hsiao B, Lo T, Chen Y, Yang C, et al.
Br J Pharmacol . 2025 Mar; PMID: 40038554
Background And Purpose: In diabetes (DM), elevated blood sugar levels contribute to the overproduction of reactive oxygen species (ROS), leading to endothelial progenitor cell (EPC) dysfunction. This study aimed to...
9.
7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death
Yang H, Jiang B, Li W, Du G, Xu F, Zhang Y, et al.
Br J Pharmacol . 2025 Mar; PMID: 40038493
Background And Purpose: Glioblastoma multiforme (GBM) is an aggressive brain tumour which drug treatment has no overall significant effect on survival rate. Sinomenine is a natural product extracted from the...
10.
An antisense oligonucleotide targeting the heat-shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis
Boutanquoi P, Pommerolle L, Dondaine L, Tanguy J, Bellaye P, Biziorek L, et al.
Br J Pharmacol . 2025 Mar; PMID: 40033950
Background And Purpose: Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by fibroblast activation and abnormal accumulation of extracellular matrix in the lungs. We previously demonstrated the importance of...