Robert C Reid
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Explore the profile of Robert C Reid including associated specialties, affiliations and a list of published articles.
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69
Citations
1308
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Recent Articles
1.
Wang Y, Curson J, Ramnath D, Das Gupta K, Reid R, Karunakaran D, et al.
Biochem J
. 2024 Oct;
481(21):1569-1584.
PMID: 39373581
Histone deacetylase 7 (HDAC7) is a member of the class IIa family of classical HDACs with important roles in cell development, differentiation, and activation, including in macrophages and other innate...
2.
Wu K, Condon N, Hill T, Reid R, Fairlie D, Lim J
J Innate Immun
. 2023 Mar;
15(1):468-484.
PMID: 36882040
Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted...
3.
Das Gupta K, Ramnath D, von Pein J, Curson J, Wang Y, Abrol R, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2212813120.
PMID: 36649417
The immune system must be able to respond to a myriad of different threats, each requiring a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase HDAC7...
4.
Sinniah E, Wu Z, Shen S, Naval-Sanchez M, Chen X, Lim J, et al.
Cell Rep
. 2022 May;
39(7):110818.
PMID: 35584683
Histone deacetylases (HDACs) are a class of enzymes that control chromatin state and influence cell fate. We evaluated the chromatin accessibility and transcriptome dynamics of zinc-containing HDACs during cell differentiation...
5.
Hesping E, Chua M, Pflieger M, Qian Y, Dong L, Bachu P, et al.
ACS Infect Dis
. 2022 Jan;
8(1):106-117.
PMID: 34985259
Malaria, caused by parasites, results in >400,000 deaths annually. There is no effective vaccine, and new drugs with novel modes of action are needed because of increasing parasite resistance to...
6.
Chen K, Guo Q, Hill T, Cui Y, Kendall A, Yang Z, et al.
Sci Adv
. 2021 Dec;
7(49):eabg4007.
PMID: 34851660
The retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane trafficking and signaling. Mutation of the retromer subunit Vps35 causes late-onset Parkinson’s disease, while viral and bacterial pathogens can hijack the...
7.
Ramnath D, Das Gupta K, Wang Y, Abrol R, Curson J, Lim J, et al.
J Leukoc Biol
. 2021 Nov;
111(2):327-336.
PMID: 34811804
TLRs reprogram macrophage metabolism, enhancing glycolysis and promoting flux through the tricarboxylic acid cycle to enable histone acetylation and inflammatory gene expression. The histone deacetylase (HDAC) family of lysine deacetylases...
8.
Chua M, Tng J, Hesping E, Fisher G, Goodman C, Skinner-Adams T, et al.
Int J Parasitol Drugs Drug Resist
. 2021 Sep;
17:118-127.
PMID: 34560571
Malaria is caused by infection with Plasmodium parasites and results in significant health and economic impacts. Malaria eradication is hampered by parasite resistance to current drugs and the lack of...
9.
Mak J, Wu K, Gupta P, Barbero S, McLaughlin M, Lucke A, et al.
J Med Chem
. 2021 Feb;
64(4):2186-2204.
PMID: 33570940
The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive...
10.
Reid R, Haugen P, Gilgien M, Kipp R, Smith G
Front Sports Act Living
. 2020 Dec;
2:25.
PMID: 33345019
Important insight into ski function, and ultimately skier technique and tactics, can be gained by studying how measured ski trajectories compare to predictions based on theoretical models of ski-snow interaction...