James McCluskey
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Explore the profile of James McCluskey including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Awad W, Mayall J, Xu W, Johansen M, Patton T, Lim X, et al.
J Exp Med
. 2025 Jan;
222(2.
PMID: 39820322
Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function....
2.
Wang H, Souter M, de Lima Moreira M, Li S, Zhou Y, Nelson A, et al.
Sci Immunol
. 2024 Dec;
9(102):eadp9841.
PMID: 39642244
Mucosal-associated invariant T (MAIT) cells are known for their rapid effector functions and antibacterial immune protection. Here, we define the plasticity of interferon-γ (IFN-γ)-producing MAIT1 and interleukin-17A (IL-17A)-producing MAIT17 cell...
3.
McInerney M, Awad W, Souter M, Kang Y, Wang C, Chan Yew Poa K, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2414792121.
PMID: 39589872
The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal-associated invariant T (MAIT) cells. MR1 can also present other metabolites to activate MR1-restricted...
4.
Edmans M, Connelley T, Morgan S, Pediongco T, Jayaraman S, Juno J, et al.
J Biol Chem
. 2024 May;
300(6):107338.
PMID: 38705391
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize small molecule metabolites presented by major histocompatibility complex class I related protein 1 (MR1), via an...
5.
Mak J, Rivero R, Hoang H, Lim X, Deng J, McWilliam H, et al.
Angew Chem Int Ed Engl
. 2024 Apr;
63(31):e202400632.
PMID: 38679861
Bacterial synthesis of vitamin B2 generates a by-product, 5-(2-oxopropylideneamino)-d-ribityl-aminouracil (5-OP-RU), with potent immunological properties in mammals, but it is rapidly degraded in water. This natural product covalently bonds to the...
6.
Ciacchi L, Mak J, Le J, Fairlie D, McCluskey J, Corbett A, et al.
J Biol Chem
. 2024 Mar;
300(5):107229.
PMID: 38537698
Mucosal-associated invariant T (MAIT) cells can elicit immune responses against riboflavin-based antigens presented by the evolutionary conserved MHC class I related protein, MR1. While we have an understanding of the...
7.
Nelson A, Wang H, Dewar P, Eddy E, Li S, Lim X, et al.
Front Immunol
. 2023 Sep;
14:1109759.
PMID: 37720229
Introduction: Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells, which mediate host immunity to microbial infection by recognizing metabolite antigens derived from microbial riboflavin synthesis presented...
8.
Mifsud N, Illing P, Ho R, Tuomisto J, Fettke H, Mullan K, et al.
Allergy
. 2023 Jul;
78(11):2980-2993.
PMID: 37452515
Allopurinol (ALP) is a successful drug used in the treatment of gout. However, this drug has been implicated in hypersensitivity reactions that can cause severe to life-threatening reactions such as...
9.
Awad W, Ciacchi L, McCluskey J, Fairlie D, Rossjohn J
Curr Opin Immunol
. 2023 Jun;
83:102351.
PMID: 37276819
Metabolite-based T-cell immunity is emerging as a major player in antimicrobial immunity, autoimmunity, and cancer. Here, small-molecule metabolites were identified to be captured and presented by the major histocompatibility complex...
10.
Ashley C, McSharry B, McWilliam H, Stanton R, Fielding C, Mathias R, et al.
Front Immunol
. 2023 Feb;
14:1107497.
PMID: 36845106
Introduction: The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells...