David B Kastrinsky
Overview
Explore the profile of David B Kastrinsky including associated specialties, affiliations and a list of published articles.
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17
Citations
771
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0
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Recent Articles
1.
Merisaari J, Denisova O, Doroszko M, Le Joncour V, Johansson P, Leenders W, et al.
Brain Commun
. 2020 Sep;
2(1):fcaa002.
PMID: 32954276
Glioblastoma is a fatal disease in which most targeted therapies have clinically failed. However, pharmacological reactivation of tumour suppressors has not been thoroughly studied as yet as a glioblastoma therapeutic...
2.
McClinch K, Avelar R, Callejas D, Izadmehr S, Wiredja D, Perl A, et al.
Cancer Res
. 2018 Jan;
78(8):2065-2080.
PMID: 29358171
Primary prostate cancer is generally treatable by androgen deprivation therapy, however, later recurrences of castrate-resistant prostate cancer (CRPC) that are more difficult to treat nearly always occur due to aberrant...
3.
Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky D, Zaware N, et al.
J Clin Invest
. 2017 May;
127(6):2081-2090.
PMID: 28504649
Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have achieved some clinical success, the inactivation of kinase signaling via...
4.
Kastrinsky D, Sangodkar J, Zaware N, McClinch K, Farrington C, Giannini H, et al.
Bioorg Med Chem
. 2017 Mar;
23(23):7487.
PMID: 28290285
No abstract available.
5.
Li C, Menconi F, Osman R, Mezei M, Jacobson E, Concepcion E, et al.
J Biol Chem
. 2015 Dec;
291(8):4079-90.
PMID: 26703475
We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring risk for autoimmune thyroid diseases...
6.
Sangodkar J, Farrington C, McClinch K, Galsky M, Kastrinsky D, Narla G
FEBS J
. 2015 Oct;
283(6):1004-24.
PMID: 26507691
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in the regulation of many cellular processes. A confirmed tumor suppressor protein, PP2A is genetically altered or functionally inactivated in many...
7.
Kastrinsky D, Sangodkar J, Zaware N, Izadmehr S, Dhawan N, Narla G, et al.
Bioorg Med Chem
. 2015 Sep;
23(19):6528-34.
PMID: 26372073
The phenothiazine and dibenzazepine tricyclics are potent neurotropic drugs with a documented but underutilized anti-cancer side effect. Reengineering these agents (TFP, CPZ, CIP) by replacing the basic amine with a...
8.
Tahlan K, Wilson R, Kastrinsky D, Arora K, Nair V, Fischer E, et al.
Antimicrob Agents Chemother
. 2012 Jan;
56(4):1797-809.
PMID: 22252828
SQ109, a 1,2-diamine related to ethambutol, is currently in clinical trials for the treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that SQ109 disrupts cell...
9.
Robertson W, Kastrinsky D, Hwang I, Boger D
Bioorg Med Chem Lett
. 2010 Apr;
20(9):2722-5.
PMID: 20381346
The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5' position of the DNA binding subunit, are described.
10.
Kastrinsky D, Barry C
Tetrahedron Lett
. 2010 Feb;
51(1):197-200.
PMID: 20161438
A concise synthesis of (14)C labeled meropenem prepared from (14)C dimethylamine hydrochloride is described. Using a similar reaction sequence, the meropenem nucleus was also attached to biotin providing a probe...