All Roads Lead to PP2A: Exploiting the Therapeutic Potential of This Phosphatase

Overview

Journal FEBS J

Specialty Biochemistry

Date 2015 Oct 29

PMID 26507691

Citations 171

Authors

Jaya Sangodkar

Caroline C Farrington

Kimberly McClinch

Matthew D Galsky

David B Kastrinsky

Goutham Narla

Affiliations

Soon will be listed here.

Abstract

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in the regulation of many cellular processes. A confirmed tumor suppressor protein, PP2A is genetically altered or functionally inactivated in many cancers highlighting a need for its therapeutic reactivation. In this review we discuss recent literature on PP2A: the elucidation of its structure and the functions of its subunits, and the identification of molecular lesions and post-translational modifications leading to its dysregulation in cancer. A final section will discuss the proteins and small molecules that modulate PP2A and how these might be used to target dysregulated forms of PP2A to treat cancers and other diseases.

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