Christopher A Werley
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Explore the profile of Christopher A Werley including associated specialties, affiliations and a list of published articles.
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26
Citations
837
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Recent Articles
11.
Werley C, Chien M, Cohen A
Biomed Opt Express
. 2018 Jan;
8(12):5794-5813.
PMID: 29296505
The rapid increase in the number and quality of fluorescent reporters and optogenetic actuators has yielded a powerful set of tools for recording and controlling cellular state and function. To...
12.
Werley C, Brookings T, Upadhyay H, Williams L, McManus O, Dempsey G
Curr Protoc Pharmacol
. 2017 Sep;
78:11.20.1-11.20.24.
PMID: 28892145
A key challenge for establishing a phenotypic screen for neuronal excitability is measurement of membrane potential changes with high throughput and accuracy. Most approaches for probing excitability rely on low-throughput,...
13.
Hempel C, Werley C, Dempsey G, Gerber D
Drug Discov Today Technol
. 2017 Jun;
23:17-25.
PMID: 28647082
There is a pressing need for new and more effective treatments for central nervous system (CNS) disorders. A large body of evidence now suggests that alterations in synaptic transmission and...
14.
Werley C, Chien M, Gaublomme J, Shekhar K, Butty V, Yi B, et al.
PLoS One
. 2017 Mar;
12(3):e0172671.
PMID: 28333933
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising platform for cardiac studies in vitro, and possibly for tissue repair in humans. However, hiPSC-CM cells tend to retain morphology,...
15.
Henderson M, Baldwin H, Werley C, Boccardo S, Whitaker L, Yan X, et al.
PLoS One
. 2015 Oct;
10(10):e0139273.
PMID: 26451944
Endoplasmic reticulum calcium homeostasis is critical for cellular functions and is disrupted in diverse pathologies including neurodegeneration and cardiovascular disease. Owing to the high concentration of calcium within the ER,...
16.
Teo S, Werley C, Wang C, Fan K, Ofori-Okai B, Zhang X, et al.
Opt Express
. 2015 Jun;
23(11):14876-96.
PMID: 26072845
We explored the use of the optically transparent semiconductor indium tin oxide (ITO) as an alternative to optically opaque metals for the fabrication of photonic structures in terahertz (THz) near-field...
17.
Teo S, Ofori-Okai B, Werley C, Nelson K
Rev Sci Instrum
. 2015 Jun;
86(5):051301.
PMID: 26026507
Multidimensional spectroscopy at visible and infrared frequencies has opened a window into the transfer of energy and quantum coherences at ultrafast time scales. For these measurements to be performed in...
18.
Chien M, Werley C, Farhi S, Cohen A
Chem Sci
. 2015 Feb;
6(3):1701-1705.
PMID: 25705368
Sorting of target cells from a heterogeneous pool is technically difficult when the selection criterion is complex, e.g. a dynamic response, a morphological feature, or a combination of multiple parameters....
19.
Zou P, Zhao Y, Douglass A, Hochbaum D, Brinks D, Werley C, et al.
Nat Commun
. 2014 Aug;
5:4625.
PMID: 25118186
Genetically encoded fluorescent reporters of membrane potential promise to reveal aspects of neural function not detectable by other means. We present a palette of multicoloured brightly fluorescent genetically encoded voltage...
20.
Hochbaum D, Zhao Y, Farhi S, Klapoetke N, Werley C, Kapoor V, et al.
Nat Methods
. 2014 Jun;
11(8):825-33.
PMID: 24952910
All-optical electrophysiology-spatially resolved simultaneous optical perturbation and measurement of membrane voltage-would open new vistas in neuroscience research. We evolved two archaerhodopsin-based voltage indicators, QuasAr1 and QuasAr2, which show improved brightness...