The Journal of General Physiology
Overview
The Journal of General Physiology is a peer-reviewed scientific journal that publishes original research articles, reviews, and commentaries in the field of physiology. It covers a wide range of topics including cellular and molecular physiology, neurophysiology, cardiovascular physiology, and muscle physiology. The journal aims to advance our understanding of fundamental physiological processes and their implications for health and disease.
Details
Details
Abbr.
J Gen Physiol
Start
1918
End
Continuing
Frequency
Monthly
p-ISSN
0022-1295
e-ISSN
1540-7748
Country
United States
Language
English
Specialty
Physiology
Metrics
Metrics
h-index / Ranks: 1660
139
SJR / Ranks: 2575
1270
CiteScore / Ranks: 3145
6.70
JIF / Ranks: 2461
3.8
Recent Articles
1.
Kellermayer D, Sulea C, Tordai H, Benke K, Polos M, Agg B, et al.
J Gen Physiol
. 2025 Mar;
157(3).
PMID: 40062891
Marfan syndrome (MFS) is an autosomal dominant disease caused by mutations in the gene (FBN1) of fibrillin-1, a major determinant of the extracellular matrix (ECM). Functional impairment in the cardiac...
2.
Medrihan L, Knudsen M, Ferraro T, Del Cioppo Vasques P, Romin Y, Fujisawa S, et al.
J Gen Physiol
. 2025 Mar;
157(3).
PMID: 40052940
The cholinergic interneurons (ChIs) of the nucleus accumbens (NAc) have a critical role in the activity of this region, specifically in the context of major depressive disorder. To understand the...
3.
Vysma M, Welsh J, Laver D
J Gen Physiol
. 2025 Mar;
157(3).
PMID: 40047651
Integrating cellular sarcoplasmic reticulum (SR) Ca2+ release with the known Ca2+ activation properties of RyR2s remains challenging. The sharp increase in SR Ca2+ permeability above a threshold SR luminal [Ca2+]...
4.
Thoreson W, Bartol T, Conoan N, Diamond J
J Gen Physiol
. 2025 Feb;
157(3).
PMID: 40019452
Synapses of retinal rod photoreceptors involve deep invaginations occupied by second-order rod bipolar cell (RBP) and horizontal cell (HC) dendrites. Synaptic vesicles are released into this invagination at multiple sites...
5.
Sahin A, Zachariae U
J Gen Physiol
. 2025 Feb;
157(3).
PMID: 39982432
Two-pore channels (TPCs) are twofold symmetric endolysosomal cation channels forming important drug targets, especially for antiviral drugs. They are activated by calcium, ligand binding, and membrane voltage, and to date,...
6.
Jennings M
J Gen Physiol
. 2025 Feb;
157(3).
PMID: 39982431
The article by Lewis et al. (https://doi.org/10.1085/jgp.202413709) in this issue of JGP describes the use of single-molecule fluorescence polarization microscopy to obtain estimates of all the rate constants for transitions...
7.
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy
Lewis J, Zhou Y, Lu Z
J Gen Physiol
. 2025 Feb;
157(3).
PMID: 39976549
To understand the mechanism underlying the ability of individual AdiC molecules to transport arginine and agmatine, we used a recently developed high-resolution single-molecule fluorescence-polarization microscopy method to investigate conformation-specific changes...
8.
Short B
J Gen Physiol
. 2025 Feb;
157(2).
PMID: 39932460
JGP study (Avilés et al. https://doi.org/10.1085/jgp.202413642) reveals that visual perception of high-frequency flickers requires signaling by the tissue polarity protein FAT3 in retinal bipolar cells.
9.
Noureddine M, Mikolajek H, Morgan N, Denning C, Loughna S, Gehmlich K, et al.
J Gen Physiol
. 2025 Feb;
157(2).
PMID: 39918740
α-actinin (ACTN) is a pivotal member of the actin-binding protein family, crucial for the anchoring and organization of actin filaments within the cytoskeleton. Four isoforms of α-actinin exist: two non-muscle...
10.
Harris A
J Gen Physiol
. 2025 Feb;
157(2).
PMID: 39907692
Gupta et al. (https://doi.org/10.1085/jgp.202413676) reconcile a disconnect between structural and functional data regarding stoichiometry of PANX1 channels and provide new insights about channel activation.