Binoj C Nair
Overview
Explore the profile of Binoj C Nair including associated specialties, affiliations and a list of published articles.
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21
Citations
626
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Recent Articles
1.
Piha-Paul S, Dumbrava E, Nair B, Xiong W, Xu L, Mostorino R, et al.
Onco Targets Ther
. 2021 May;
14:3037-3049.
PMID: 33994796
Background: Crizotinib inhibits ALK, MET and ROS1 tyrosine kinases but the development of resistance to monotherapy is an issue. The anti-angiogenic properties of pazopanib could overcome crizotinib drug resistance. Additionally,...
2.
Rosen E, Johnson M, Clifford S, Somwar R, Kherani J, Son J, et al.
Clin Cancer Res
. 2020 Oct;
27(1):34-42.
PMID: 33082208
Purpose: The proto-oncogene encodes a receptor tyrosine kinase that is activated by gene fusion in 1%-2% of non-small cell lung cancers (NSCLC) and rarely in other cancer types. Selpercatinib is...
3.
Sareddy G, Pratap U, Viswanadhapalli S, Pitta Venkata P, Nair B, Krishnan S, et al.
Neurooncol Adv
. 2020 Apr;
1(1):vdz042.
PMID: 32309805
Background: Glioblastoma (GBM) is a deadly neoplasm of the central nervous system. The molecular mechanisms and players that contribute to GBM development is incompletely understood. Methods: The expression of PELP1...
4.
Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair B, et al.
EMBO Rep
. 2018 Feb;
19(3).
PMID: 29420235
Caseinolytic peptidase P (ClpP) is a mammalian quality control protease that is proposed to play an important role in the initiation of the mitochondrial unfolded protein response (UPR), a retrograde...
5.
Liu J, Viswanadhapalli S, Garcia L, Zhou M, Nair B, Kost E, et al.
Oncotarget
. 2017 Jun;
8(30):50002-50014.
PMID: 28654894
Ovarian cancer is the deadliest of all gynecologic cancers. Despite success with initial chemotherapy, the majority of patients relapse with an incurable disease. Development of chemotherapy resistance is a major...
6.
Deepa S, Bhaskaran S, Ranjit R, Qaisar R, Nair B, Liu Y, et al.
Free Radic Biol Med
. 2016 Jan;
91:281-92.
PMID: 26721594
The caseinolytic peptidase P (ClpP) is the endopeptidase component of the mitochondrial matrix ATP-dependent ClpXP protease. ClpP degrades unfolded proteins to maintain mitochondrial protein homeostasis and is involved in the...
7.
Sorokin A, Nair B, Wei Y, Aziz K, Evdokimova V, Hung M, et al.
Cancer Res
. 2015 Apr;
75(9):1846-58.
PMID: 25877877
The protein tyrosine phosphatase receptor PTPRN2 is expressed predominantly in endocrine and neuronal cells, where it functions in exocytosis. We found that its immature isoform proPTPRN2 is overexpressed in various...
8.
Krishnan S, Nair B, Sareddy G, Roy S, Natarajan M, Suzuki T, et al.
Breast Cancer Res Treat
. 2015 Mar;
150(3):487-99.
PMID: 25788226
Triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype, occurs in younger women and is associated with poor prognosis. Gain-of-function mutations in TP53 are a frequent occurrence in TNBC...
9.
Sareddy G, Nair B, Krishnan S, Gonugunta V, Zhang Q, Suzuki T, et al.
Oncotarget
. 2012 Dec;
4(1):18-28.
PMID: 23248157
Glioma development is a multistep process, involving alterations in genetic and epigenetic mechanisms. Understanding the mechanisms and enzymes that promote epigenetic changes in gliomas are urgently needed to identify novel...
10.
Ghosal G, Leung J, Nair B, Fong K, Chen J
J Biol Chem
. 2012 Aug;
287(41):34225-33.
PMID: 22902628
DNA damage-induced proliferating cell nuclear antigen (PCNA) ubiquitination serves as the key event mediating post-replication repair. Post-replication repair involves either translesion synthesis (TLS) or damage avoidance via template switching. In...