Aberrant Expression of ProPTPRN2 in Cancer Cells Confers Resistance to Apoptosis

Overview

Journal Cancer Res

Specialty Oncology

Date 2015 Apr 17

PMID 25877877

Citations 14

Authors

Alexey V Sorokin

Binoj C Nair

Yongkun Wei

Kathryn E Aziz

Valentina Evdokimova

Mien-Chie Hung

Junjie Chen

Affiliations

Soon will be listed here.

Abstract

The protein tyrosine phosphatase receptor PTPRN2 is expressed predominantly in endocrine and neuronal cells, where it functions in exocytosis. We found that its immature isoform proPTPRN2 is overexpressed in various cancers, including breast cancer. High proPTPRN2 expression was associated strongly with lymph node-positive breast cancer and poor clinical outcome. Loss of proPTPRN2 in breast cancer cells promoted apoptosis and blocked tumor formation in mice, whereas enforced expression of proPTPRN2 in nontransformed human mammary epithelial cells exerted a converse effect. Mechanistic investigations suggested that ProPTPRN2 elicited these effects through direct interaction with TRAF2, a hub scaffold protein for multiple kinase cascades, including ones that activate NF-κB. Overall, our results suggest PTPRN2 as a novel candidate biomarker and therapeutic target in breast cancer.

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