Gangadhara R Sareddy
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Explore the profile of Gangadhara R Sareddy including associated specialties, affiliations and a list of published articles.
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52
Citations
861
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Recent Articles
1.
Onishi S, Jayamohan S, Chowdhury A, Rivas S, Otani Y, Murphy S, et al.
Res Sq
. 2025 Feb;
PMID: 39989968
Background: Despite multi-model therapy of maximal surgical resection, radiation, chemotherapy, and tumor-treating fields, glioblastoma patients show dismal prognosis. Protein Arginine Methyltransferase 5 (PRMT5) is overexpressed in glioblastoma and its inhibition...
2.
Nassar K, Yang X, Baker A, Gopalam R, Arnold W, Adeniran T, et al.
Cancer Res Commun
. 2024 Sep;
4(10):2610-2620.
PMID: 39258975
Significance: HCC is one of the leading causes of cancer fatalities in the United States. Effective targeted therapeutics for HCC are urgently needed. In this study, we show that PELP1...
3.
Balinda H, Kelly W, Kaklamani V, Lathrop K, Canola M, Ghamasaee P, et al.
Nat Commun
. 2024 Aug;
15(1):6707.
PMID: 39112464
Sacituzumab Govitecan (SG) is an antibody-drug conjugate that has demonstrated efficacy in patients with TROP-2 expressing epithelial cancers. In a xenograft model of intracranial breast cancer, SG inhibited tumor growth...
4.
Chen Y, Johnson J, Jayamohan S, He Y, Venkata P, Jamwal D, et al.
Mol Carcinog
. 2024 Jul;
63(10):2026-2039.
PMID: 38990091
Ovarian cancer (OCa) is the deadliest of all gynecological cancers. The standard treatment for OCa is platinum-based chemotherapy, such as carboplatin or cisplatin in combination with paclitaxel. Most patients are...
5.
Ebrahimi B, Viswanadhapalli S, Pratap U, Rahul G, Yang X, Pitta Venkata P, et al.
NPJ Precis Oncol
. 2024 May;
8(1):118.
PMID: 38789520
Of all gynecologic cancers, epithelial-ovarian cancer (OCa) stands out with the highest mortality rates. Despite all efforts, 90% of individuals who receive standard surgical and cytotoxic therapy experience disease recurrence....
6.
Liu X, Viswanadhapalli S, Kumar S, Lee T, Moore A, Ma S, et al.
Nat Cancer
. 2024 May;
5(6):953.
PMID: 38769429
No abstract available.
7.
Collier A, Viswanadhapalli S, Gopalam R, Lee T, Kassees K, Parra K, et al.
Cancers (Basel)
. 2024 Feb;
16(3).
PMID: 38339252
Ovarian cancer (OCa) is the most lethal form of gynecologic cancer, and the tumor heterogeneities at the molecular, cellular, and tissue levels fuel tumor resistance to standard therapies and pose...
8.
Johnson J, Alejo S, Jayamohan S, Sareddy G
Expert Opin Ther Targets
. 2023 Nov;
27(12):1177-1188.
PMID: 37997756
Introduction: Lysine-specific histone demethylase 1A (KDM1A/LSD1) has emerged as an important therapeutic target in various cancer types. LSD1 regulates a wide range of biological processes that influence cancer development, progression,...
9.
Yang X, Liu Z, Tang W, Pratap U, Collier A, Altwegg K, et al.
Mol Oncol
. 2023 Oct;
18(9):2136-2156.
PMID: 37853941
Endometrial carcinoma (ECa) is the fourth most common cancer among women. The oncogene PELP1 is frequently overexpressed in a variety of cancers, including ECa. We recently generated SMIP34, a small-molecule...
10.
Wang M, Li W, Tomimatsu N, Yu C, Ji J, Alejo S, et al.
Mol Cell
. 2023 Oct;
83(20):3679-3691.e8.
PMID: 37797621
The tumor-suppressor breast cancer 1 (BRCA1) in complex with BRCA1-associated really interesting new gene (RING) domain 1 (BARD1) is a RING-type ubiquitin E3 ligase that modifies nucleosomal histone and other...