Sathyaseelan S Deepa
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Explore the profile of Sathyaseelan S Deepa including associated specialties, affiliations and a list of published articles.
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35
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1253
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Recent Articles
1.
Mohammed S, Ohene-Marfo P, Jiang C, Peng Z, Thadathil N, Tran A, et al.
Geroscience
. 2025 Feb;
PMID: 39930289
Chronic, low-grade inflammation is a hallmark of aging and various age-related diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). The prevalence of metabolic dysfunction-associated steatohepatitis (MASH), an advanced form of...
2.
Selvarani R, Nguyen H, Pazhanivel N, Raman M, Lee S, Wolf R, et al.
Geroscience
. 2024 Nov;
PMID: 39514172
Non-resolving, chronic inflammation (inflammaging) is believed to play an important role in aging and age-related diseases. The goal of this study was to determine if inflammation induced by necroptosis arising...
3.
Ohene-Marfo P, Nguyen H, Mohammed S, Thadathil N, Tran A, Nicklas E, et al.
Int J Mol Sci
. 2024 Mar;
25(5).
PMID: 38474061
Chronic inflammation is a key player in metabolic dysfunction-associated fatty liver disease (MAFLD) progression. Necroptosis, an inflammatory cell death pathway, is elevated in MAFLD patients and mouse models, yet its...
4.
Deepa S, Thadathil N, Corral J, Mohammed S, Pham S, Rose H, et al.
Cell Calcium
. 2024 Mar;
119:102854.
PMID: 38430790
The necroptotic effector molecule MLKL accumulates in neurons over the lifespan of mice, and its downregulation has the potential to improve cognition through neuroinflammation, and changes in the abundance of...
5.
Ohene-Marfo P, Nguyen H, Mohammed S, Thadathil N, Tran A, Nicklas E, et al.
bioRxiv
. 2024 Jan;
PMID: 38260537
Chronic inflammation is a key player in metabolic dysfunction-associated fatty liver disease (MAFLD) progression. Necroptosis, an inflammatory cell death pathway, is elevated in MAFLD patients and mouse models, yet its...
6.
Kotey S, Tan X, Fleming O, Kasiraju R, Dagnell A, Van Pelt K, et al.
Geroscience
. 2023 Dec;
46(2):2739-2754.
PMID: 38159133
Aging has a significant impact on the immune system, leading to a gradual decline in immune function and changes in the body's ability to respond to bacterial infections. Non-tuberculous mycobacteria...
7.
Selvarani R, Nguyen H, Thadathil N, Wolf R, Freeman W, Wiley C, et al.
Geroscience
. 2023 Oct;
45(6):3241-3256.
PMID: 37792157
To study the impact of necroptosis-induced chronic inflammation on age-related diseases and aging, two knockin mouse models (Ripk3-KI and Mlkl-KI) were generated that overexpress two genes involved in necroptosis (Ripk3...
8.
Mohammed S, Thadathil N, Ohene-Marfo P, Tran A, Van Der Veldt M, Georgescu C, et al.
Mol Cancer Res
. 2023 May;
21(9):933-946.
PMID: 37204757
Implications: Necroptosis is a major contributor to hepatic inflammation that drives the progression of NAFLD to HCC and therefore represents a valid target for NAFLD-mediated HCC.
9.
Bhaskaran S, Kumar G, Thadathil N, Piekarz K, Mohammed S, Lopez S, et al.
Redox Biol
. 2022 Dec;
59():102550.
PMID: 36470129
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease. Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord by deletion of Mn-Superoxide dismutase...
10.
Thadathil N, Selvarani R, Mohammed S, Nicklas E, Tran A, Kamal M, et al.
Aging Cell
. 2022 Jul;
21(8):e13676.
PMID: 35869934
The goal of this study was to test the role cellular senescence plays in the increased inflammation, chronic liver disease, and hepatocellular carcinoma seen in mice null for Cu/Zn-Superoxide dismutase...