Rajeshwar Rao Tekmal
Overview
Explore the profile of Rajeshwar Rao Tekmal including associated specialties, affiliations and a list of published articles.
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35
Citations
765
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Recent Articles
1.
Spencer N, Sanchez A, Gopalam R, Subbarayalu P, Medina D, Yang X, et al.
Int J Mol Sci
. 2023 Dec;
24(24).
PMID: 38139260
Endometrial cancer (ECa) is the most common female gynecologic cancer. When comparing the two histological subtypes of endometrial cancer, Type II tumors are biologically more aggressive and have a worse...
2.
Viswanadhapalli S, Ma S, Sareddy G, Lee T, Li M, Gilbreath C, et al.
Breast Cancer Res
. 2019 Dec;
21(1):150.
PMID: 31878959
Background: CDK4/6 inhibitors in combination with endocrine therapy (AE/AI/SERDs) are approved for the treatment of ER+ advanced breast cancer (BCa). However, not all patients benefit from CDK4/6 inhibitors therapy. We...
3.
Raj G, Sareddy G, Ma S, Lee T, Viswanadhapalli S, Li R, et al.
Elife
. 2017 Aug;
6.
PMID: 28786813
The majority of human breast cancer is estrogen receptor alpha (ER) positive. While anti-estrogens/aromatase inhibitors are initially effective, resistance to these drugs commonly develops. Therapy-resistant tumors often retain ER signaling,...
4.
Liu J, Viswanadhapalli S, Garcia L, Zhou M, Nair B, Kost E, et al.
Oncotarget
. 2017 Jun;
8(30):50002-50014.
PMID: 28654894
Ovarian cancer is the deadliest of all gynecologic cancers. Despite success with initial chemotherapy, the majority of patients relapse with an incurable disease. Development of chemotherapy resistance is a major...
5.
Sareddy G, Li X, Liu J, Viswanadhapalli S, Garcia L, Gruslova A, et al.
Sci Rep
. 2016 Apr;
6:24185.
PMID: 27126081
Glioblastomas (GBM), deadly brain tumors, have greater incidence in males than females. Epidemiological evidence supports a tumor suppressive role of estrogen; however, estrogen as a potential therapy for GBM is...
6.
Gonugunta V, Sareddy G, Krishnan S, Cortez V, Roy S, Tekmal R, et al.
Mol Cancer Ther
. 2014 Apr;
13(6):1578-88.
PMID: 24688046
Proline, Glutamic acid-, and Leucine-rich Protein 1 (PELP1) is a proto-oncogene that modulates estrogen receptor (ER) signaling. PELP1 expression is upregulated in breast cancer, contributes to therapy resistance, and is...
7.
Sareddy G, Nair B, Gonugunta V, Zhang Q, Brenner A, Brann D, et al.
Mol Cancer Ther
. 2012 Mar;
11(5):1174-82.
PMID: 22442308
Gliomas are the most common and devastating central nervous system neoplasms. A gender bias exists in their development: females are at lower risk than males, implicating estrogen-mediated protective effects. Estrogen...
8.
Budrys N, Nair H, Liu Y, Kirma N, Binkley P, Kumar S, et al.
Fertil Steril
. 2012 Feb;
97(5):1129-35.e1.
PMID: 22365076
Objective: To investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis. Design: In vivo and vitro study. Setting: University-based academic medical center. Patient(s):...
9.
Nair H, Perla R, Kirma N, Krishnegowda N, Ganapathy M, Rajhans R, et al.
Horm Cancer
. 2011 Oct;
3(1-2):26-36.
PMID: 22006184
Breast cancers amplified for the tyrosine kinase receptor Her-2/neu constitute ~30% of advanced breast cancer cases, and are characterized by hormone independence and aggressive growth, implicating this pathway in breast...
10.
Aligeti S, Kirma N, Binkley P, Schenken R, Tekmal R
Fertil Steril
. 2011 Apr;
95(8):2464-6.
PMID: 21481374
Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role...