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Anna Herman-Antosiewicz

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Citations 2441
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Recent Articles
1.
Pyrczak-Felczykowska A, Kaczorowska A, Gieldon A, Braczko A, Smolenski R, Antosiewicz J, et al.
J Enzyme Inhib Med Chem . 2025 Feb; 40(1):2465575. PMID: 40013402
The impact of the isoxazole derivative of usnic acid, (formerly known as 2b) on cancer and non-cancerous cell metabolism was investigated. significantly reduced the utilisation of most metabolic substrates that...
2.
Pyrczak-Felczykowska A, Herman-Antosiewicz A
Int J Mol Sci . 2025 Feb; 26(3). PMID: 39941144
Cancer is a multifaceted disease characterised by uncontrolled cellular proliferation and metastasis, resulting in significant global mortality. Current therapeutic strategies, including surgery, chemotherapy, and radiation therapy, face challenges such as...
3.
Brokowska J, Herman-Antosiewicz A, Hac A
Eur J Nutr . 2024 Dec; 64(1):46. PMID: 39680190
Purpose: Autophagy is a degradation process whose activation underlies beneficial effects of caloric restriction. Isothiocyanates (ITCs) induce autophagy in cancer cells, however, their impact on primary cells remains insufficiently explored,...
4.
Gimla M, Herman-Antosiewicz A
Biomedicines . 2024 Oct; 12(10). PMID: 39457512
Cancer, a complex group of diseases marked by uncontrolled cell growth and invasive behavior, is characterized by distinct hallmarks acquired during tumor development. These hallmarks, first proposed by Douglas Hanahan...
5.
Gimla M, Pyrczak-Felczykowska A, Malinowska M, Hac A, Narajczyk M, Bylinska I, et al.
Cancer Cell Int . 2023 Sep; 23(1):210. PMID: 37743482
Background: Pancreatic cancer is one of the leading causes of cancer death in Western societies. Its late diagnosis and resistance to chemotherapies result in a high mortality rate; thus, the...
6.
Gunawan G, Gimla M, Gardiner M, Herman-Antosiewicz A, Reekie T
Bioorg Med Chem . 2023 Jan; 79:117157. PMID: 36652792
Natural products continue to be an inspiration for new drugs to treat debilitating diseases such as cancer. Usnic acid is a secondary metabolite isolated predominately from lichen species and has...
7.
Pyrczak-Felczykowska A, Reekie T, Jakalski M, Hac A, Malinowska M, Pawlik A, et al.
Int J Mol Sci . 2022 Feb; 23(3). PMID: 35163724
Derivatives of usnic acid (UA), a secondary metabolite from lichens, were synthesized to improve its anticancer activity and selectivity. Recently we reported the synthesis and activity of an UA isoxazole...
8.
Zdrowowicz M, Spisz P, Hac A, Herman-Antosiewicz A, Rak J
Int J Mol Sci . 2022 Feb; 23(3). PMID: 35163354
Radiotherapy is a crucial cancer treatment, but its outcome is still far from satisfactory. One of the reasons that cancer cells show resistance to ionizing radiation is hypoxia, defined as...
9.
Krause K, Pyrczak-Felczykowska A, Karczewska M, Narajczyk M, Herman-Antosiewicz A, Szalewska-Palasz A, et al.
Int J Mol Sci . 2021 Oct; 22(19). PMID: 34638525
represents a constant threat to public health, causing widespread infections, especially in developing countries with a significant number of fatalities and serious complications every year. The standard treatment by oral...
10.
Hac A, Pierzynowska K, Herman-Antosiewicz A
Cells . 2021 Apr; 10(4). PMID: 33920542
Autophagy is a specific macromolecule and organelle degradation process. The target macromolecule or organelle is first enclosed in an autophagosome, and then delivered along acetylated microtubules to the lysosome. Autophagy...