Andreas Raue
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Explore the profile of Andreas Raue including associated specialties, affiliations and a list of published articles.
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30
Citations
1183
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Recent Articles
1.
Tam E, Fulton R, Sampson J, Muda M, Camblin A, Richards J, et al.
Sci Transl Med
. 2019 Oct;
11(512).
PMID: 31578241
Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced...
2.
Steiert B, Kreutz C, Raue A, Timmer J
Methods Mol Biol
. 2019 Apr;
1945:341-362.
PMID: 30945255
Mechanistic models of biomolecular processes are established research tools that enable to quantitatively investigate dynamic features of biological processes such as signal transduction cascades. Often, these models aim at describing...
3.
Casaletto J, Geddie M, Abu-Yousif A, Masson K, Fulgham A, Boudot A, et al.
Proc Natl Acad Sci U S A
. 2019 Mar;
116(15):7533-7542.
PMID: 30898885
Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as amplification or receptor overexpression, has been implicated in driving...
4.
Kumar M, Du J, Lagoudas G, Jiao Y, Sawyer A, Drummond D, et al.
Cell Rep
. 2018 Nov;
25(6):1458-1468.e4.
PMID: 30404002
Tumor ecosystems are composed of multiple cell types that communicate by ligand-receptor interactions. Targeting ligand-receptor interactions (for instance, with immune checkpoint inhibitors) can provide significant benefits for patients. However, our...
5.
Alkan O, Schoeberl B, Shah M, Koshkaryev A, Heinemann T, Drummond D, et al.
Sci Signal
. 2018 Jul;
11(540).
PMID: 30042127
Cells respond to DNA damage by activating complex signaling networks that decide cell fate, promoting not only DNA damage repair and survival but also cell death. We have developed a...
6.
Schelker M, Feau S, Du J, Ranu N, Klipp E, MacBeath G, et al.
Nat Commun
. 2017 Dec;
8(1):2032.
PMID: 29230012
As interactions between the immune system and tumour cells are governed by a complex network of cell-cell interactions, knowing the specific immune cell composition of a solid tumour may be...
7.
Sobotta S, Raue A, Huang X, Vanlier J, Junger A, Bohl S, et al.
Front Physiol
. 2017 Oct;
8:775.
PMID: 29062282
IL-6 is a central mediator of the immediate induction of hepatic acute phase proteins (APP) in the liver during infection and after injury, but increased IL-6 activity has been associated...
8.
Hass H, Masson K, Wohlgemuth S, Paragas V, Allen J, Sevecka M, et al.
NPJ Syst Biol Appl
. 2017 Sep;
3:27.
PMID: 28944080
Targeted therapies have shown significant patient benefit in about 5-10% of solid tumors that are addicted to a single oncogene. Here, we explore the idea of ligand addiction as a...
9.
Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, et al.
J Biol Chem
. 2017 Feb;
292(15):6291-6302.
PMID: 28223354
The IL-1β induced activation of the p38/MAPK-activated protein kinase 2 (MK2) pathway in hepatocytes is important for control of the acute phase response and regulation of liver regeneration. Many aspects...
10.
Maiwald T, Hass H, Steiert B, Vanlier J, Engesser R, Raue A, et al.
PLoS One
. 2016 Sep;
11(9):e0162366.
PMID: 27588423
In systems biology, one of the major tasks is to tailor model complexity to information content of the data. A useful model should describe the data and produce well-determined parameter...