Aiga Grandane
Overview
Explore the profile of Aiga Grandane including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
12
Citations
163
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Zelencova-Gopejenko D, Videja M, Grandane A, Pudnika-Okincica L, Sipola A, Vilks K, et al.
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982599
Heart-type fatty-acid binding protein (FABP3) is an essential cytosolic lipid transport protein found in cardiomyocytes. FABP3 binds fatty acids (FAs) reversibly and with high affinity. Acylcarnitines (ACs) are an esterified...
2.
Zelencova-Gopejenko D, Grandane A, Loza E, Lola D, Sipola A, Liepinsh E, et al.
ACS Med Chem Lett
. 2022 Nov;
13(11):1723-1729.
PMID: 36385923
ε-Trimethyllysine dioxygenase (TMLD) is a non-heme Fe(II) and α-ketoglutarate dependent oxygenase that catalyzes the stereospecific hydroxylation of ε-trimethyl--lysine (TML) to β-hydroxy-TML during the first step of -carnitine biosynthesis. Targeting TMLD...
3.
Vilks K, Videja M, Makrecka-Kuka M, Katkevics M, Sevostjanovs E, Grandane A, et al.
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34208786
The accumulation of lipid intermediates may interfere with energy metabolism pathways and regulate cellular energy supplies. As increased levels of long-chain acylcarnitines have been linked to insulin resistance, we investigated...
4.
Grandane A, Nocentini A, Domraceva I, Zalubovskis R, Supuran C
Eur J Med Chem
. 2020 May;
200:112300.
PMID: 32460112
Oxathiino[6,5-b]pyridine 2,2-dioxides are identified as a new class of isoform-selective nanomolar inhibitors of tumor associated human carbonic anhydrases (hCA) IX and XII. At the same time they do not inhibit...
5.
Grandane A, Nocentini A, Werner T, Zalubovskis R, Supuran C
Bioorg Med Chem
. 2020 Apr;
28(11):115496.
PMID: 32327349
Benzoxepinones ("homocoumarins") are identified as a new class of selective inhibitors for tumor associated human carbonic anhydrases (hCA, EC 4.2.1.1) isoforms IX and XII. Similar to coumarins, they do not...
6.
Krasavin M, Zalubovskis R, Grandane A, Domraceva I, Zhmurov P, Supuran C
J Enzyme Inhib Med Chem
. 2020 Jan;
35(1):506-510.
PMID: 31928252
The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms CA IX and - CA XII is being able to also inhibit thioredoxin reductase...
7.
Grandane A, Longwitz L, Roolf C, Spannenberg A, Murua Escobar H, Junghanss C, et al.
J Org Chem
. 2018 Dec;
84(3):1320-1329.
PMID: 30557512
A straightforward two-step synthesis of benzoxepinones was developed via base-free phosphane-catalyzed Wittig reaction. 3-Methyl-1-phenyl-2-phospholene 1-oxide was used as a precatalyst and trimethoxysilane as a reducing agent. Additionally benzoic acid is...
8.
Grandane A, Tanc M, Di Cesare Mannelli L, Carta F, Ghelardini C, Zalubovskis R, et al.
J Med Chem
. 2015 Apr;
58(9):3975-83.
PMID: 25875209
6-Substituted sulfocoumarins bearing the carboxamido, trimethylammonium as well as the cyano and methoxy moieties with interesting inhibitory activity/selectivity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA IX...
9.
Grandane A, Tanc M, Zalubovskis R, Supuran C
Bioorg Med Chem
. 2015 Mar;
23(7):1430-6.
PMID: 25753329
A series of 6-aryl-substituted 1,2-benzoxathiine 2,2-dioxides was obtained by reacting 6-iodo-sulfocoumarin with arylboronic acids in Suzuki cross-coupling conditions. The new sulfocoumarins incorporating various substituted phenyl moieties in position 6 of...
10.
Grandane A, Tanc M, Zalubovskis R, Supuran C
Bioorg Med Chem Lett
. 2014 Feb;
24(5):1256-60.
PMID: 24518190
A series of 6-substituted sulfocoumarins incorporating substituted-1,2,3-triazol-4-yl-/5-yl moieties were synthesized by employing click chemistry. The new sulfocoumarins incorporated cycloalkyl, tert-butyl and substituted aryl moieties at the triazole ring, and were...