Alessio Nocentini
Overview
Explore the profile of Alessio Nocentini including associated specialties, affiliations and a list of published articles.
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Articles
244
Citations
2409
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Recent Articles
1.
Martinez-Montiel M, Arrighi G, Begines P, Gonzalez-Bakker A, Puerta A, Fernandes M, et al.
Int J Mol Sci
. 2025 Feb;
26(3).
PMID: 39940992
The selective inhibition of key enzymes, such as carbonic anhydrases (CAs IX and XII), which are overexpressed in cancer tissues, has emerged as a promising strategy in cancer research. However,...
2.
Elkotamy M, Abdelrahman M, Giovannuzzi S, Alkabbani M, Nocentini A, Supuran C, et al.
Int J Biol Macromol
. 2025 Jan;
303:140462.
PMID: 39884639
This study presents the design, synthesis, and evaluation of a novel series of coumarin-based compounds (9a-t) as potential anticancer agents. The compounds were strategically designed to inhibit cancer-related carbonic anhydrase...
3.
Nencetti S, Cuffaro D, Ciccone L, Nocentini A, Di Stefano M, Poli G, et al.
Future Med Chem
. 2025 Jan;
17(3):271-285.
PMID: 39878534
Aim: Human carbonic anhydrases (hCAs) are involved in many physiological processes including respiration, pH control, ion transport, bone resorption, and gastric fluid secretion. Recently, CA IX and CA XII have...
4.
Giovannuzzi S, Angeli A, Begines P, Ferraroni M, Nocentini A, Supuran C
ACS Med Chem Lett
. 2025 Jan;
16(1):163-166.
PMID: 39811134
The tetrazole group is here proposed as a zinc-binding warhead for the inhibition of the metalloenzyme carbonic anhydrases. A set of synthesized derivatives incorporating the tetrazole moiety were evaluated as...
5.
Paoletti N, Giovannuzzi S, Bonardi A, De Luca V, Capasso C, Nocentini A, et al.
Arch Pharm (Weinheim)
. 2024 Dec;
358(1):e2400814.
PMID: 39686870
This study investigates aliphatic sulfonamide derivatives as inhibitors of the α-, β-, and γ-class carbonic anhydrase (CA) isoforms from Vibrio cholerae (VchCAs). A series of 26 compounds bearing a triazole...
6.
Berrino E, Michelet B, Vitse K, Nocentini A, Bartolucci G, Martin-Mingot A, et al.
J Med Chem
. 2024 Oct;
67(21):19460-19474.
PMID: 39447020
Carbonic anhydrase (CA) IV is a membrane-bound enzyme involved in important physio-pathological processes, such as excitation-contraction coupling in heart muscle, central nervous system (CNS) extracellular buffering, and mediation of inflammatory...
7.
Begines P, Bonardi A, Giovannuzzi S, Nocentini A, Gratteri P, De Luca V, et al.
Chem Biol Interact
. 2024 Oct;
404:111284.
PMID: 39442681
The role of carbonic anhydrases isoforms (CAs) IX and XII in the pathogenesis and progression of many types of solid tumors is well known. In this context, selective CA inhibitors...
8.
Giovannuzzi S, Nikitjuka A, Angeli A, Smietana M, Massardi M, Turati M, et al.
J Med Chem
. 2024 Oct;
67(20):18221-18234.
PMID: 39378331
The benzoxaborinine scaffold, a homologue of benzoxaborole with an additional carbon atom in the boracycle, shows significant potential in developing new therapeutic agents. This study reports the synthesis, inhibition assays...
9.
Bonardi A, Nocentini A, De Luca V, Capasso C, Elkaeed E, Eldehna W, et al.
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337494
This study proposes a novel therapeutic strategy for cancer management by combining the antitumor effects of hydrogen sulfide (HS) and inhibition of carbonic anhydrases (CAs; EC 4.2.1.1), specifically isoforms IV,...
10.
Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases
Nocentini A, Costa A, Bonardi A, Ammara A, Giovannuzzi S, Petreni A, et al.
J Med Chem
. 2024 Sep;
67(18):16873-16898.
PMID: 39283654
This study introduces a novel multitargeting strategy that combines carbonic anhydrase (CA) activators and cholinesterase (ChE) inhibitors to enhance cognitive functions. A series of tacrine-based derivatives with amine/amino acid moieties...