Bone Mineral Density and Risk Factors for Osteoporosis--a Population-based Study of 1600 Perimenopausal Women

Overview

Journal Calcif Tissue Int

Specialty Pathology

Date 1994 Jul 1

PMID 7922782

Citations 49

Authors

H Kroger

M Tuppurainen

R Honkanen

E Alhava

S Saarikoski

Affiliations

Soon will be listed here.

Abstract

Population-based epidemiological studies on osteoporosis are few. Our study evaluated the effects of menopause and certain putative behavioural risk factors on bone mineral density (BMD). Spinal and femoral neck BMD were measured with dual X-ray absorptiometry (DXA) from 1600 perimenopausal women aged 48-59 years (mean 53.2 years) with no diseases or medications known to affect bone metabolism. These women were a selected sample of the Kuopio Osteoporosis Risk Factor and Prevention Study population (n = 14,220). There was a wide variation of BMD among perimenopausal women. Menopause had a major effect on BMD. Postmenopausal women had significantly lower BMD in both spine (-6.2%) and femoral neck (-3.9%) as compared with premenopausal women. Multiple regression analysis showed that weight, menopausal status, age, and grip strength were significant independent predictors of both spinal and femoral BMD. Additionally, physical activity was found to be a significant predictor of femoral BMD, and alcohol consumption was a significant predictor of spinal BMD. However, current anthropometric and lifestyle factors explained only 18.7-25.4% of the variability of BMD. Therefore, the estimation of the risk factor status at menopause is not an adequate substitute for bone densitometry. However, our results may in part help clinicians to identify the risk groups at which to direct bone density measurements.

Citing Articles

A pilot study investigating the influence of dietary boron levels on osteoporosis in postmenopausal women.

Rababah T, Aludatt M, Gammoh S, Salameh F, Magableh G, Almajwal A Food Sci Nutr. 2024; 12(8):5708-5721.

PMID: 39139931 PMC: 11317700. DOI: 10.1002/fsn3.4218.

The diagnostic cut-off points for components of sarcopenia in Finnish Caucasian women: A retrospective cross-sectional study.

Sjoblom S, Suuronen J, Rikkonen T, Honkanen R, Kroger H, Sirola J J Frailty Sarcopenia Falls. 2023; 8(4):211-220.

PMID: 38046438 PMC: 10690131. DOI: 10.22540/JFSF-08-211.

Prevalence and risk factors of osteoporosis detected by dual-energy X-ray absorptiometry among Chinese patients with primary biliary cholangitis.

Chen J, Liu Y, Bi Y, Wang X World J Gastroenterol. 2023; 29(29):4580-4592.

PMID: 37621753 PMC: 10445004. DOI: 10.3748/wjg.v29.i29.4580.

Knowledge and understanding risk factors and preventive measures for osteoporosis in women: results of a survey in 502 women with and without a migration background.

Taghvaei R, Dimitrova D, Karaman M, Sehouli J BMC Musculoskelet Disord. 2022; 23(1):824.

PMID: 36042427 PMC: 9429362. DOI: 10.1186/s12891-022-05773-0.

Effects of a single intravaneous dose of zoledronic acid on bone healing following tooth extraction in ovariectomized rabbits.

Mavi E, Hocaoglu P Saudi Dent J. 2021; 33(7):724-730.

PMID: 34803326 PMC: 8589606. DOI: 10.1016/j.sdentj.2020.03.016.

References

Gavaler J, Van Thiel D . The association between moderate alcoholic beverage consumption and serum estradiol and testosterone levels in normal postmenopausal women: relationship to the literature. Alcohol Clin Exp Res. 1992; 16(1):87-92. DOI: 10.1111/j.1530-0277.1992.tb00642.x. View

Cummings S, Black D, Nevitt M, Browner W, Cauley J, Ensrud K . Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet. 1993; 341(8837):72-5. DOI: 10.1016/0140-6736(93)92555-8. View

Dequeker J . The relationship between osteoporosis and osteoarthritis. Clin Rheum Dis. 1985; 11(2):271-96. View

Laitinen K, Valimaki M, Keto P . Bone mineral density measured by dual-energy X-ray absorptiometry in healthy Finnish women. Calcif Tissue Int. 1991; 48(4):224-31. DOI: 10.1007/BF02556372. View

Masud T, Langley S, Wiltshire P, Doyle D, Spector T . Effect of spinal osteophytosis on bone mineral density measurements in vertebral osteoporosis. BMJ. 1993; 307(6897):172-3. PMC: 1678366. DOI: 10.1136/bmj.307.6897.172. View

Krall E, Dawson-Hughes B . Heritable and life-style determinants of bone mineral density. J Bone Miner Res. 1993; 8(1):1-9. DOI: 10.1002/jbmr.5650080102. View

Pocock N, Eisman J, Yeates M, Sambrook P, Eberl S, Wren B . Limitations of forearm bone densitometry as an index of vertebral or femoral neck osteopenia. J Bone Miner Res. 1986; 1(4):369-75. DOI: 10.1002/jbmr.5650010410. View

van Beresteijn E, van t Hof M, Schaafsma G, de Waard H, Duursma S . Habitual dietary calcium intake and cortical bone loss in perimenopausal women: a longitudinal study. Calcif Tissue Int. 1990; 47(6):338-44. DOI: 10.1007/BF02555884. View

Stevenson J, Whitehead M, Padwick M, Endacott J, Sutton C, Banks L . Dietary intake of calcium and postmenopausal bone loss. BMJ. 1988; 297(6640):15-7. PMC: 1834138. DOI: 10.1136/bmj.297.6640.15. View

10.

Mazess R, Barden H . Bone density in premenopausal women: effects of age, dietary intake, physical activity, smoking, and birth-control pills. Am J Clin Nutr. 1991; 53(1):132-42. DOI: 10.1093/ajcn/53.1.132. View

11.

Cooper C, Atkinson E, Wahner H, OFallon W, Riggs B, Judd H . Is caffeine consumption a risk factor for osteoporosis?. J Bone Miner Res. 1992; 7(4):465-71. DOI: 10.1002/jbmr.5650070415. View

12.

Kroger H, Heikkinen J, Laitinen K, Kotaniemi A . Dual-energy X-ray absorptiometry in normal women: a cross-sectional study of 717 Finnish volunteers. Osteoporos Int. 1992; 2(3):135-40. DOI: 10.1007/BF01623820. View

13.

Hui S, Slemenda C, JOHNSTON Jr C . Baseline measurement of bone mass predicts fracture in white women. Ann Intern Med. 1989; 111(5):355-61. DOI: 10.7326/0003-4819-111-5-355. View

14.

Goldsmith N, Johnston J . Bone mineral: effects of oral contraceptives, pregnancy, and lactation. J Bone Joint Surg Am. 1975; 57(5):657-68. View

15.

Sinaki M, Wahner H, Offord K, Hodgson S . Efficacy of nonloading exercises in prevention of vertebral bone loss in postmenopausal women: a controlled trial. Mayo Clin Proc. 1989; 64(7):762-9. DOI: 10.1016/s0025-6196(12)61748-0. View

16.

GORDON G, SOUTHREN A, VITTEK J, Lieber C . The effect of alcohol ingestion on hepatic aromatase activity and plasma steroid hormones in the rat. Metabolism. 1979; 28(1):20-4. DOI: 10.1016/0026-0495(79)90163-x. View

17.

Bouxsein M, Lewis B, Charette S, Weinstein P, Marcus R . Muscle strength as a predictor of bone mineral density in young women. J Bone Miner Res. 1990; 5(6):589-95. DOI: 10.1002/jbmr.5650050608. View

18.

Pocock N, Eisman J, Kelly P, Sambrook P, Yeates M . Effects of tobacco use on axial and appendicular bone mineral density. Bone. 1989; 10(5):329-31. DOI: 10.1016/8756-3282(89)90128-2. View

19.

Lindsay R . The growing problem of osteoporosis. Osteoporos Int. 1992; 2(6):267-8. DOI: 10.1007/BF01623180. View

20.

Spector T, Edwards A, Thompson P . Use of a risk factor and dietary calcium questionnaire in predicting bone density and subsequent bone loss at the menopause. Ann Rheum Dis. 1992; 51(11):1252-3. PMC: 1012467. DOI: 10.1136/ard.51.11.1252. View