A Pilot Study Investigating the Influence of Dietary Boron Levels on Osteoporosis in Postmenopausal Women

Overview

Journal Food Sci Nutr

Specialty Biotechnology

Date 2024 Aug 14

PMID 39139931

Authors

Taha Rababah

Muhammad Aludatt

Sana Gammoh

Feras Bani Salameh

Ghazi Magableh

Ali Almajwal

Sevil Yucel

Yara Al-Rayyan

Numan Al-Rayyan

Affiliations

Soon will be listed here.

Abstract

This study aimed to evaluate the impact of dietary boron on osteoporosis in postmenopausal Jordanian women. Sixty-six women diagnosed with osteoporosis were recruited and data on personal information, dietary habits, medical history, and lifestyle were collected. Bone mineral density, serum calcium, and serum vitamin D measurements were obtained from patient records. This study showed a strong correlation between boron intake and bone mineral density in these women with osteoporosis and a negative correlation between boron intake and serum calcium ( < .05). However, no significant correlation was found between boron intake and various parameters such as serum vitamin D, dietary habits, body mass index (BMI), waist circumference (WC), age of menopause, cases of hysterectomy or oophorectomy, location of fractures, education level, social status, smoking, and physical activity ( > .05). A significant link was found between boron intake and bone mineral density highlighting the importance of nutritional and lifestyle factors affecting bone health. Further research on the specific impact of boron is warranted to better inform dietary interventions for osteoporosis prevention and management.

Citing Articles

Commentary on "A Pilot Study Investigating the Influence of Dietary Boron Levels on Osteoporosis in Postmenopausal Women".

Ullah B Food Sci Nutr. 2025; 13(1):e4646.

PMID: 39803297 PMC: 11716985. DOI: 10.1002/fsn3.4646.

References

Gullberg B, Johnell O, Kanis J . World-wide projections for hip fracture. Osteoporos Int. 1997; 7(5):407-13. DOI: 10.1007/pl00004148. View

Pourhashem Z, Bayani M, Noreddini H, Bijani A, Hosseini S . Prevalence of osteoporosis and its association with serum vitamin D level in older people in Amirkola, North of Iran. Caspian J Intern Med. 2015; 3(1):347-53. PMC: 4600130. View

Dalsky G, Stocke K, Ehsani A, Slatopolsky E, Lee W, BIRGE Jr S . Weight-bearing exercise training and lumbar bone mineral content in postmenopausal women. Ann Intern Med. 1988; 108(6):824-8. DOI: 10.7326/0003-4819-108-6-824. View

Maalouf G, Bachour F, Hlais S, Maalouf N, Yazbeck P, Yaghi Y . Epidemiology of hip fractures in Lebanon: a nationwide survey. Orthop Traumatol Surg Res. 2013; 99(6):675-80. DOI: 10.1016/j.otsr.2013.04.009. View

Naghii M, Torkaman G, Mofid M . Effects of boron and calcium supplementation on mechanical properties of bone in rats. Biofactors. 2007; 28(3-4):195-201. DOI: 10.1002/biof.5520280306. View

Takeuchi A, Reddy G, Kobayashi T, Okano T, Park J, Sharma S . Nuclear factor of activated T cells (NFAT) as a molecular target for 1alpha,25-dihydroxyvitamin D3-mediated effects. J Immunol. 1998; 160(1):209-18. View

Sellami S, Sahli H, Meddeb N, Hamza S, Chahed M, Ben MBarek R . [Prevalence of osteoporotic fractures in Tunisian women]. Rev Chir Orthop Reparatrice Appar Mot. 2006; 92(5):490-4. DOI: 10.1016/s0035-1040(06)75836-6. View

Naghii M, Wall P, Samman S . The boron content of selected foods and the estimation of its daily intake among free-living subjects. J Am Coll Nutr. 1996; 15(6):614-9. DOI: 10.1080/07315724.1996.10718638. View

. Prevention and management of osteoporosis. World Health Organ Tech Rep Ser. 2004; 921:1-164, back cover. View

10.

Park K, Nam J, Choi J . The short vitamin D receptor is associated with increased risk for generalized aggressive periodontitis. J Clin Periodontol. 2006; 33(8):524-8. DOI: 10.1111/j.1600-051X.2006.00944.x. View

11.

Murray F . A comparative review of the pharmacokinetics of boric acid in rodents and humans. Biol Trace Elem Res. 1999; 66(1-3):331-41. DOI: 10.1007/BF02783146. View

12.

Richold M . Boron exposure from consumer products. Biol Trace Elem Res. 1999; 66(1-3):121-9. DOI: 10.1007/BF02783132. View

13.

Moayyeri A . The association between physical activity and osteoporotic fractures: a review of the evidence and implications for future research. Ann Epidemiol. 2008; 18(11):827-35. DOI: 10.1016/j.annepidem.2008.08.007. View

14.

Hidayet N, Sharaf S, Aref S, Tawfik T, Moubarak I . Correlates of age at natural menopause: a community-based study in Alexandria. East Mediterr Health J. 2000; 5(2):307-19. View

15.

Kanis J, Johansson H, Johnell O, Oden A, De Laet C, Eisman J . Alcohol intake as a risk factor for fracture. Osteoporos Int. 2004; 16(7):737-42. DOI: 10.1007/s00198-004-1734-y. View

16.

Palacios C . The role of nutrients in bone health, from A to Z. Crit Rev Food Sci Nutr. 2006; 46(8):621-8. DOI: 10.1080/10408390500466174. View

17.

Abelow B, Holford T, Insogna K . Cross-cultural association between dietary animal protein and hip fracture: a hypothesis. Calcif Tissue Int. 1992; 50(1):14-8. DOI: 10.1007/BF00297291. View

18.

Glade M . Vitamin D: health panacea or false prophet?. Nutrition. 2012; 29(1):37-41. DOI: 10.1016/j.nut.2012.05.010. View

19.

Naghii M, Samman S . The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Biol Trace Elem Res. 1997; 56(3):273-86. DOI: 10.1007/BF02785299. View

20.

Dennison E, Mohamed M, Cooper C . Epidemiology of osteoporosis. Rheum Dis Clin North Am. 2007; 32(4):617-29. DOI: 10.1016/j.rdc.2006.08.003. View