A Study of the Link Between Bone Turnover Markers and Bone Mineral Density with Inflammation and Body Mass in Postmenopausal Women with Active Rheumatoid Arthritis

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2012 Nov 29

PMID 23188554

Citations 6

Authors

Anna Straburzynska-Lupa

Alicja Nowak

Wojciech Romanowski

Pawel Korman

Lucja Pilaczynska-Szczesniak

Affiliations

Soon will be listed here.

Abstract

In this study, the levels of bone turnover markers (BTMs) and bone mineral density (BMD) were studied in relation to body mass and several inflammatory markers, in postmenopausal patients with rheumatoid arthritis (RA). Fifty-nine postmenopausal women with active RA (lean, overweight, obese) were studied. The femoral BMD and serum levels of BTMs: osteocalcin (OC) and collagen type I cross-linked C-telopeptide fragments (CTX), and osteopontin (OPN), resistin, high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor (TNF)-α in these patients were measured. It has been noticed that obese women had significantly higher total femoral BMD and total T-score compared to the lean subjects (p ≤ 0.01). The significant associations of BMD measures and CTX levels with body mass parameters (p ≤ 0.01 and p < 0.05, respectively) were found. Values of neck BMD adjusted for BMI were inversely associated with concentrations of TNF-α (p < 0.05). Osteocalcin levels inversely correlated with resistin (p ≤ 0.01) and CTX levels positively correlated with OPN (p ≤ 0.01). There were found no associations between BTMs and BMD with other inflammatory indices. Inverse correlations between OPN levels and body mass (p < 0.05), waist circumference (p < 0.05), and duration of postmenopausal period (p ≤ 0.01) were observed. Findings of the present study suggest that body mass and inflammatory markers, most of all OPN, resistin and TNF-α, play an important role in bone metabolism in postmenopausal women with active RA.

Citing Articles

Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease.

Soliman E, Ohrndorf S, Zehairy M, Matrawy K, Alhadidy A, Abdelati A BMC Musculoskelet Disord. 2024; 25(1):195.

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The Effect of Whole-Body Cryotherapy at Different Temperatures on Proinflammatory Cytokines, Oxidative Stress Parameters, and Disease Activity in Patients with Ankylosing Spondylitis.

Straburzynska-Lupa A, Kasprzak M, Romanowski M, Kwasniewska A, Romanowski W, Iskra M Oxid Med Cell Longev. 2018; 2018:2157496.

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Lean Mass and Disease Activity are the Best Predictors of Bone Mineral Loss in the Premenopausal Women with Rheumatoid Arthritis.

Sharma M, Dhakad U, Wakhlu A, Bhadu D, Dutta D, Das S Indian J Endocrinol Metab. 2018; 22(2):236-243.

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Authors' reply.

Sipahioglu S Acta Orthop Traumatol Turc. 2016; 50(6):708.

PMID: 27839944 PMC: 6197550. DOI: 10.1016/j.aott.2015.11.002.

Bone remodelling markers in rheumatoid arthritis.

Fardellone P, Sejourne A, Paccou J, Goeb V Mediators Inflamm. 2014; 2014:484280.

PMID: 24839355 PMC: 4009257. DOI: 10.1155/2014/484280.

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