Combined Effects of Estrogen Deficiency and Cadmium Exposure on Calcified Hard Tissues: Animal Model Relating to Itai-itai Disease in Postmenopausal Women

Overview

Journal Proc Jpn Acad Ser B Phys Biol Sci

Specialties Biology
Science

Date 2013 Jul 26

PMID 23883612

Citations 4

Authors

Mitsuo Kakei

Toshiro Sakae

Masayoshi Yoshikawa

Affiliations

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Abstract

Using ovariectomized rats as a model of postmenopausal women, we studied the effects of estrogen (Es) deficiency and in combination with cadmium (Cd) exposure on the calcified hard tissues related to the development of itai-itai disease. Es deficiency suppressed the synthesis of carbonic anhydrase required for the crystal nucleation process, causing the crystal structure defects in the tooth enamel. Regarding the combined effects of Es deficiency and Cd exposure on the bone, in which rats were given drinking water containing Cd ions, soft X-ray radiography revealed a development of labyrinthine pattern in the calvaria, and micro-computed tomography demonstrated the declining trabecular architecture of the tibia, suggesting Cd-induced osteoporotic change. Further, electron microscopy showed the increase of amorphous minerals in the calvaria. In conclusion, the combined effects of Es deficiency and Cd exposure can be responsible for accelerating the declining bone strength together with the crystal structure defects resulting in the preferential occurrence of itai-itai disease in postmenopausal women.(Communicated by Tatsuo SUDA, M.J.A.).

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References

Wronski T, Lowry P, Walsh C, Ignaszewski L . Skeletal alterations in ovariectomized rats. Calcif Tissue Int. 1985; 37(3):324-8. DOI: 10.1007/BF02554882. View

Kakei M, Sakae T, Yoshikawa M . Mechanism of cadmium induced crystal defects in developing rat tooth enamel. Proc Jpn Acad Ser B Phys Biol Sci. 2009; 85(10):500-7. PMC: 3621555. DOI: 10.2183/pjab.85.500. View

Casciani F, Etz E, Newbury D, Doty S . Raman microprobe studies of two mineralizing tissues: enamel of the rat incisor and the embryonic chick tibia. Scan Electron Microsc. 1979; (2):383-91. View

Bradford M . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-54. DOI: 10.1016/0003-2697(76)90527-3. View

Cummings S, Kelsey J, Nevitt M, ODowd K . Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev. 1985; 7:178-208. DOI: 10.1093/oxfordjournals.epirev.a036281. View

Itokawa Y, Abe T, TABEI R, Tanaka S . Renal and skeletal lesions in experimental cadmium poisoning: histological and biochemical approaches. Arch Environ Health. 1974; 28(3):149-54. DOI: 10.1080/00039896.1974.10666456. View

Jarup L, Alfven T, Persson B, Toss G, Elinder C . Cadmium may be a risk factor for osteoporosis. Occup Environ Med. 1998; 55(7):435-9. PMC: 1757608. DOI: 10.1136/oem.55.7.435. View

Kalu D . Evaluation of the pathogenesis of skeletal changes in ovariectomized rats. Endocrinology. 1984; 115(2):507-12. DOI: 10.1210/endo-115-2-507. View

Hiratsuka H, Katsuta O, Toyota N, Tsuchitani M, Akiba T, Marumo F . Iron deposition at mineralization fronts and osteoid formation following chronic cadmium exposure in ovariectomized rats. Toxicol Appl Pharmacol. 1997; 143(2):348-56. DOI: 10.1006/taap.1996.8101. View

10.

Nakahara H, Kakei M . TEM observations on the crystallites of dentin and bone. Josai Shika Daigaku Kiyo. 1984; 13(2):259-63. View

11.

Nakahara H, Kakei M . The central dark line in developing enamel crystallite: an electron microscopic study. Josai Shika Daigaku Kiyo. 1983; 12(1):1-6. View

12.

Genant H, Cooper C, Poor G, Reid I, Ehrlich G, Kanis J . Interim report and recommendations of the World Health Organization Task-Force for Osteoporosis. Osteoporos Int. 2000; 10(4):259-64. DOI: 10.1007/s001980050224. View

13.

Jin T, Nordberg G, Ye T, Bo M, Wang H, Zhu G . Osteoporosis and renal dysfunction in a general population exposed to cadmium in China. Environ Res. 2004; 96(3):353-9. DOI: 10.1016/j.envres.2004.02.012. View

14.

Kido T, Nogawa K, Honda R, Tsuritani I, Ishizaki M, Yamada Y . The association between renal dysfunction and osteopenia in environmental cadmium-exposed subjects. Environ Res. 1990; 51(1):71-82. DOI: 10.1016/s0013-9351(05)80183-5. View

15.

Robinson J, Harris S, Riggs B, Spelsberg T . Estrogen regulation of human osteoblastic cell proliferation and differentiation. Endocrinology. 1997; 138(7):2919-27. DOI: 10.1210/endo.138.7.5277. View

16.

Chaudhry S, Brock A, Sickles A, Patel B, Hegstad R, Johnston S . Cadmium effects on bone metabolism: accelerated resorption in ovariectomized, aged beagles. Toxicol Appl Pharmacol. 1992; 113(2):274-83. DOI: 10.1016/0041-008x(92)90125-c. View

17.

Kakei M, Nakahara H, Tamura N, Itoh H, Kumegawa M . Behavior of carbonate and magnesium ions in the initial crystallites at the early developmental stages of the rat calvaria. Ann Anat. 1997; 179(4):311-6. DOI: 10.1016/S0940-9602(97)80065-9. View

18.

Alfven T, Elinder C, Carlsson M, Grubb A, Hellstrom L, Persson B . Low-level cadmium exposure and osteoporosis. J Bone Miner Res. 2000; 15(8):1579-86. DOI: 10.1359/jbmr.2000.15.8.1579. View

19.

Katsuta O, Hiratsuka H, Matsumoto J, Iwata H, Toyota N, Tsuchitani M . Cadmium-induced osteomalacic and osteopetrotic lesions in ovariectomized rats. Toxicol Appl Pharmacol. 1994; 126(1):58-68. DOI: 10.1006/taap.1994.1090. View

20.

Kalu D, Liu C, Hardin R, Hollis B . The aged rat model of ovarian hormone deficiency bone loss. Endocrinology. 1989; 124(1):7-16. DOI: 10.1210/endo-124-1-7. View