Bone Mineral Density Among Korean Females Aged 20-50 years: Influence of Age at Menarche (The Korea National Health and Nutrition Examination Survey 2008-2011)

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2017 Mar 16

PMID 28293690

Citations 10

Authors

H K Chang

D-G Chang

J-P Myong

J-H Kim

S-J Lee

Y S Lee

H-N Lee

K H Lee

D C Park

C J Kim

S Y Hur

J S Park

T C Park

Affiliations

Soon will be listed here.

Abstract

Introduction: To investigate any correlation between bone mineral density (BMD) and age at menarche in Korean females using data from the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-V; 2008-2011).

Methods: In total, 37,753 individuals participated in health examination surveys between 2008 and 2011. A total of 5032 premenopausal females aged 20-50 years were eligible. Age, height, weight, and age at menarche were assessed.

Results: Results from the univariate linear regression and analysis of covariance (ANCOVA) indicated that age (per 1 year), height (per 1 cm), weight (per 1 kg), exercise (per 1 day/week), familial osteoporosis history (yes), parity (n = 0 to ≥4), and menarche age distribution were associated with BMD of the total femur, femur neck, and lumbar spine. After stratifying the bone area and adjusting for age, parity, alcohol intake, smoking, exercise, and familial osteoporosis history, no effect was seen for the total femur or femur neck. Age at menarche 16~17 and ≥18 years groups were associated with BMD of the lumbar spine only.

Conclusions: Age at menarche had a small but significant association with BMD of the lumbar spine in premenopausal Korean females, aged 20-50 years. Females with late menarche may achieve lower peak bone mass at some skeletal sites, which may put them at greater risk for osteoporosis in later life.

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