Low Handgrip Strength is Associated with Low Bone Mineral Density and Fragility Fractures in Postmenopausal Healthy Korean Women

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2012 Jul 13

PMID 22787368

Citations 25

Authors

Sang Wook Kim

Hyang Ah Lee

Eun-Hee Cho

Affiliations

Soon will be listed here.

Abstract

Osteoporosis is a widely recognized health problem in postmenopausal women. Osteoporotic fractures reduce independency, limit daily living activities, and increase the mortality rate. Epidemiological studies have demonstrated that low handgrip strength is a risk factor for functional limitations and disabilities, and all-cause mortality. We investigated the relationship between handgrip strength and bone mineral density (BMD) of the spine, femur neck, and total hip, as well the relationship between handgrip strength and previous fragility fractures in 337 healthy postmenopausal Korean women (mean age of 59.5 ± 6.8 yr) who were free of diseases or medications affecting bone metabolism. Age and handgrip strength were associated with BMD of the spine, femur neck, and total hip in multiple regression models. Low handgrip strength (odds ratio [OR], 0.925; range, 0.877 to 0.975; P = 0.004) and low femur neck BMD (OR, 0.019; range, 0.001 to 0.354; P = 0.008) were independent predictors of previous fragility fractures in a multiple regression model. Our results demonstrate that low handgrip strength is associated with low BMD of the spine, femur neck, and total hip, and with increased risk of previous fragility fractures.

Citing Articles

Handgrip and its relation to age, fragility fractures, and BMD between sexes in a population aged 50+ years.

Amarowicz J, Warzecha M, Krawczyk A Prz Menopauzalny. 2025; 23(4):167-172.

PMID: 39811384 PMC: 11726189. DOI: 10.5114/pm.2024.145947.

Hand grip strength and all-cause mortality risk in individuals with decreased bone mass: a study from NHANES database.

Sun H, Liu J, Tan R, Zhang X, Qian X, Qi C Front Med (Lausanne). 2024; 11:1452811.

PMID: 39722828 PMC: 11668780. DOI: 10.3389/fmed.2024.1452811.

Effects of Frailty Syndrome on Osteoporosis, Focusing on the Mediating Effect of Muscle Strength and Balance in Community-Dwelling Older Adults (≥60 years) in Iran: Results From the Amirkola Health and Aging Project Cohort Study.

Shamsalinia A, Hosseini S, Bijani A, Ghadimi R, Kordbageri M, Saadati K Geriatr Orthop Surg Rehabil. 2024; 15:21514593241264647.

PMID: 39070931 PMC: 11273585. DOI: 10.1177/21514593241264647.

Developing and comparing deep learning and machine learning algorithms for osteoporosis risk prediction.

Qiu C, Su K, Luo Z, Tian Q, Zhao L, Wu L Front Artif Intell. 2024; 7:1355287.

PMID: 38919268 PMC: 11196804. DOI: 10.3389/frai.2024.1355287.

Eight Weeks of Intermittent Exercise in Hypoxia, with or without a Low-Carbohydrate Diet, Improves Bone Mass and Functional and Physiological Capacity in Older Adults with Type 2 Diabetes.

Kindlovits R, Sousa A, Viana J, Milheiro J, Oliveira B, Marques F Nutrients. 2024; 16(11).

PMID: 38892557 PMC: 11173956. DOI: 10.3390/nu16111624.

References

Lindsey C, Brownbill R, Bohannon R, Ilich J . Association of physical performance measures with bone mineral density in postmenopausal women. Arch Phys Med Rehabil. 2005; 86(6):1102-7. DOI: 10.1016/j.apmr.2004.09.028. View

Theou O, Jones G, Jakobi J, Mitnitski A, Vandervoort A . A comparison of the relationship of 14 performance-based measures with frailty in older women. Appl Physiol Nutr Metab. 2011; 36(6):928-38. DOI: 10.1139/h11-116. View

Foley K, Owings T, Pavol M, Grabiner M . Maximum grip strength is not related to bone mineral density of the proximal femur in older adults. Calcif Tissue Int. 1999; 64(4):291-4. DOI: 10.1007/s002239900621. View

Garcia P, Dias J, Dias R, Santos P, Zampa C . A study on the relationship between muscle function, functional mobility and level of physical activity in community-dwelling elderly. Rev Bras Fisioter. 2011; 15(1):15-22. View

Young D, Masaki K, Curb J . Associations of physical activity with performance-based and self-reported physical functioning in older men: the Honolulu Heart Program. J Am Geriatr Soc. 1995; 43(8):845-54. DOI: 10.1111/j.1532-5415.1995.tb05525.x. View

Ling C, Taekema D, de Craen A, Gussekloo J, Westendorp R, Maier A . Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study. CMAJ. 2010; 182(5):429-35. PMC: 2842834. DOI: 10.1503/cmaj.091278. View

Dixon W, Lunt M, Pye S, Reeve J, Felsenberg D, Silman A . Low grip strength is associated with bone mineral density and vertebral fracture in women. Rheumatology (Oxford). 2005; 44(5):642-6. DOI: 10.1093/rheumatology/keh569. View

Bayramoglu M, Sozay S, Karatas M, Kilinc S . Relationships between muscle strength and bone mineral density of three body regions in sedentary postmenopausal women. Rheumatol Int. 2005; 25(7):513-7. DOI: 10.1007/s00296-004-0475-8. View

Rantanen T, Guralnik J, Foley D, Masaki K, Leveille S, Curb J . Midlife hand grip strength as a predictor of old age disability. JAMA. 1999; 281(6):558-60. DOI: 10.1001/jama.281.6.558. View

10.

Choquette S, Bouchard D, Doyon C, Senechal M, Brochu M, Dionne I . Relative strength as a determinant of mobility in elders 67-84 years of age. a nuage study: nutrition as a determinant of successful aging. J Nutr Health Aging. 2010; 14(3):190-5. DOI: 10.1007/s12603-010-0047-4. View

11.

Rantanen T, Harris T, Leveille S, Visser M, Foley D, Masaki K . Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. J Gerontol A Biol Sci Med Sci. 2000; 55(3):M168-73. DOI: 10.1093/gerona/55.3.m168. View

12.

Martin S, Neale G, Elia M . Factors affecting maximal momentary grip strength. Hum Nutr Clin Nutr. 1985; 39(2):137-47. View

13.

Norman K, Stobaus N, Gonzalez M, Schulzke J, Pirlich M . Hand grip strength: outcome predictor and marker of nutritional status. Clin Nutr. 2010; 30(2):135-42. DOI: 10.1016/j.clnu.2010.09.010. View

14.

Albrand G, Munoz F, Sornay-Rendu E, Duboeuf F, Delmas P . Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study. Bone. 2003; 32(1):78-85. DOI: 10.1016/s8756-3282(02)00919-5. View

15.

Kroger H, Tuppurainen M, Honkanen R, Alhava E, Saarikoski S . Bone mineral density and risk factors for osteoporosis--a population-based study of 1600 perimenopausal women. Calcif Tissue Int. 1994; 55(1):1-7. DOI: 10.1007/BF00310160. View

16.

Taekema D, Gussekloo J, Maier A, Westendorp R, de Craen A . Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old. Age Ageing. 2010; 39(3):331-7. DOI: 10.1093/ageing/afq022. View