Wine and Bone Health: a Review
Overview
Affiliations
A light-to-moderate wine consumption has been shown to provide several beneficial effects on the skeletal system, including reduced risk of bone mass loss and fractures. Wine is rich in phenolic compounds, strong phytoestrogens and natural antioxidants, to which bone protection is mainly attributed. The objective of this review was to give an overview of the exact mechanisms by which wine consumption is involved in bone protection. We found a great variety of in vitro research on the beneficial effects of isolated wine phenolics on the skeletal system, with a significant lack of evidence of their in vivo effects. In addition, we found almost no studies investigating how wine, a mixture of these phenolics dissolved in ethanol, affects the skeletal system. Our results warrant further research on this interesting topic.
Wu Y, Chao J, Bao M, Zhang N, Wang L Hereditas. 2025; 162(1):7.
PMID: 39856786 PMC: 11760116. DOI: 10.1186/s41065-025-00371-1.
Wine, Polyphenols, and the Matrix Effect: Is Alcohol Always the Same?.
Miraldi E, Baini G, Biagi M, Cappellucci G, Giordano A, Vaccaro F Int J Mol Sci. 2024; 25(18).
PMID: 39337284 PMC: 11432751. DOI: 10.3390/ijms25189796.
Lai B, Jiang H, Gao R, Zhou X Arch Osteoporos. 2024; 19(1):21.
PMID: 38546895 DOI: 10.1007/s11657-024-01382-7.
Trius-Soler M, Tresserra-Rimbau A, Moreno J, Peris P, Estruch R, Lamuela-Raventos R Front Nutr. 2022; 9:1014140.
PMID: 36458171 PMC: 9705783. DOI: 10.3389/fnut.2022.1014140.
Godos J, Giampieri F, Chisari E, Micek A, Paladino N, Forbes-Hernandez T Int J Environ Res Public Health. 2022; 19(3).
PMID: 35162537 PMC: 8835521. DOI: 10.3390/ijerph19031515.