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Wine and Bone Health: a Review

Overview
Specialty Endocrinology
Date 2015 Apr 3
PMID 25832032
Citations 8
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Abstract

A light-to-moderate wine consumption has been shown to provide several beneficial effects on the skeletal system, including reduced risk of bone mass loss and fractures. Wine is rich in phenolic compounds, strong phytoestrogens and natural antioxidants, to which bone protection is mainly attributed. The objective of this review was to give an overview of the exact mechanisms by which wine consumption is involved in bone protection. We found a great variety of in vitro research on the beneficial effects of isolated wine phenolics on the skeletal system, with a significant lack of evidence of their in vivo effects. In addition, we found almost no studies investigating how wine, a mixture of these phenolics dissolved in ethanol, affects the skeletal system. Our results warrant further research on this interesting topic.

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References
1.
Deng X, Deitrich R . Ethanol metabolism and effects: nitric oxide and its interaction. Curr Clin Pharmacol. 2008; 2(2):145-53. PMC: 2562584. DOI: 10.2174/157488407780598135. View

2.
Choi E, Hwang J . Effects of (+)-catechin on the function of osteoblastic cells. Biol Pharm Bull. 2003; 26(4):523-6. DOI: 10.1248/bpb.26.523. View

3.
Tucker K, Jugdaohsingh R, Powell J, Qiao N, Hannan M, Sripanyakorn S . Effects of beer, wine, and liquor intakes on bone mineral density in older men and women. Am J Clin Nutr. 2009; 89(4):1188-96. PMC: 2667462. DOI: 10.3945/ajcn.2008.26765. View

4.
Habold C, Momken I, Ouadi A, Bekaert V, Brasse D . Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension. J Bone Miner Metab. 2010; 29(1):15-22. DOI: 10.1007/s00774-010-0187-y. View

5.
Waterhouse A . Wine phenolics. Ann N Y Acad Sci. 2002; 957:21-36. DOI: 10.1111/j.1749-6632.2002.tb02903.x. View