Sexual Dimorphism and the Multi-omic Response to Exercise Training in Rat Subcutaneous White Adipose Tissue

Overview

Journal Nat Metab

Publisher Springer Nature

Specialty Endocrinology

Date 2024 May 1

PMID 38693320

Authors

Gina M Many

James A Sanford

Tyler J Sagendorf

Zhenxin Hou

Pasquale Nigro

Katie L Whytock

David Amar

Tiziana Caputo

Nicole R Gay

David A Gaul

Michael F Hirshman

David Jimenez-Morales

Malene E Lindholm

Michael J Muehlbauer

Maria Vamvini

Bryan C Bergman

Facundo M Fernandez

Laurie J Goodyear

Andrea L Hevener

Eric A Ortlund

Lauren M Sparks

Ashley Xia

Joshua N Adkins

Sue C Bodine

Christopher B Newgard

Simon Schenk

Affiliations

Soon will be listed here.

Abstract

Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.

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