Simon Schenk
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Explore the profile of Simon Schenk including associated specialties, affiliations and a list of published articles.
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101
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4596
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Recent Articles
1.
Fitzgerald L, Reynoso Spurrier C, Lau N, Melamed M, Burnett L, Meyer G, et al.
bioRxiv
. 2025 Jan;
PMID: 39868315
Mitochondria are key regulators of metabolism and ATP supply in skeletal muscle, while circadian rhythms influence many physiological processes. However, whether mitochondrial function is intrinsically regulated in a circadian manner...
2.
Jones J, Zhou J, Dong J, Huitron-Resendiz S, Boussaty E, Chavez E, et al.
J Biol Chem
. 2024 Sep;
300(10):107756.
PMID: 39260699
Aminoacyl-tRNA synthetases are fundamental to the translation machinery with emerging roles in transcriptional regulation. Previous cellular studies have demonstrated tyrosyl-tRNA synthetase (YARS1 or TyrRS) as a stress response protein through...
3.
Fitzgerald L, Bremner S, Ward S, Cho Y, Schenk S
Function (Oxf)
. 2024 Aug;
5(6).
PMID: 39134511
A growing body of data suggests that skeletal muscle contractile function and glucose metabolism vary by time-of-day, with chronobiological effects on intrinsic skeletal muscle properties being proposed as the underlying...
4.
Schenk S, Sagendorf T, Many G, Lira A, de Sousa L, Bae D, et al.
Function (Oxf)
. 2024 Jul;
5(4).
PMID: 38984994
While regular physical activity is a cornerstone of health, wellness, and vitality, the impact of endurance exercise training on molecular signaling within and across tissues remains to be delineated. The...
5.
Fitzgerald L, Bremner S, Ward S, Cho Y, Schenk S
bioRxiv
. 2024 May;
PMID: 38798320
Impact Statement: testing demonstrates that there is no time-of-day variation in the intrinsic contractile properties of skeletal muscle (including no effect on force production or endurance) or contraction-stimulated glucose uptake.
6.
Meyer G, Ferey J, Sanford J, Fitzgerald L, Greenberg A, Svensson K, et al.
J Appl Physiol (1985)
. 2024 May;
136(6):1559-1567.
PMID: 38722753
Mice with skeletal muscle-specific and inducible double knockout of the lysine acetyltransferases, p300 (E1A binding protein p300) and CBP (cAMP-response element-binding protein binding protein), referred to as i-mPCKO, demonstrate a...
7.
Amar D, Gay N, Jimenez-Morales D, Jean Beltran P, Ramaker M, Raja A, et al.
Cell Metab
. 2024 May;
36(6):1411-1429.e10.
PMID: 38701776
Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium...
8.
Many G, Sanford J, Sagendorf T, Hou Z, Nigro P, Whytock K, et al.
Nat Metab
. 2024 May;
6(5):963-979.
PMID: 38693320
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape...
9.
Fowler A, Knaus K, Khuu S, Khalilimeybodi A, Schenk S, Ward S, et al.
Exp Physiol
. 2024 Apr;
109(6):939-955.
PMID: 38643471
Exercise-induced muscle adaptations vary based on exercise modality and intensity. We constructed a signalling network model from 87 published studies of human or rodent skeletal muscle cell responses to endurance...
10.
Meyer G, Ferey J, Sanford J, Fitzgerald L, Greenberg A, Svensson K, et al.
bioRxiv
. 2024 Mar;
PMID: 38463996
New & Noteworthy: The mechanism underlying dramatic loss of muscle contractile function with inducible deletion of both p300 and CBP in skeletal muscle remains unknown. Here we find that impairments...