Michael F Hirshman
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Explore the profile of Michael F Hirshman including associated specialties, affiliations and a list of published articles.
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100
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5878
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Recent Articles
1.
Xu Y, Alves-Wagner A, Inada H, Firouzjah S, Osana S, Amir M, et al.
Cell Rep
. 2024 Sep;
43(10):114789.
PMID: 39325622
Offspring growth requires establishing maternal behavior associated with the maternal endocrine profile. Placentae support the adaptations of the mother, producing bioactive molecules that affect maternal organs. We recently reported that...
2.
Carapeto P, Iwasaki K, Hela F, Kahng J, Alves-Wagner A, Middelbeek R, et al.
Nat Metab
. 2024 Sep;
6(10):1976-1990.
PMID: 39317751
Beta (β)-cell senescence contributes to type 2 diabetes mellitus (T2DM). While exercise is vital for T2DM management and significantly affects cellular ageing markers, its effect on β-cell senescence remains unexplored....
3.
Vamvini M, Nigro P, Caputo T, Stanford K, Hirshman M, Middelbeek R, et al.
Cell Rep
. 2024 Jul;
43(7):114481.
PMID: 39003734
Exercise training and cold exposure both improve systemic metabolism, but the mechanisms are not well established. Here, we tested the hypothesis that inguinal white adipose tissue (iWAT) adaptations are critical...
4.
Many G, Sanford J, Sagendorf T, Hou Z, Nigro P, Whytock K, et al.
Nat Metab
. 2024 May;
6(5):963-979.
PMID: 38693320
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape...
5.
Vamvini M, Nigro P, Caputo T, Stanford K, Hirshman M, Middelbeek R, et al.
bioRxiv
. 2023 Oct;
PMID: 37905018
Exercise training and cold exposure both improve systemic metabolism, but the mechanisms are not well-established. We tested the hypothesis that adaptations to inguinal white adipose tissue (iWAT) are critical for...
6.
Zhang H, Simpson L, Carbone N, Hirshman M, Nigro P, Vamvini M, et al.
iScience
. 2023 Jul;
26(7):107226.
PMID: 37485354
Physical activity is important for type 2 diabetes treatment, yet the underlying mechanisms for these beneficial effects of exercise are not fully understood. Here, we investigated the effects of exercise...
7.
Nigro P, Vamvini M, Yang J, Caputo T, Ho L, Carbone N, et al.
Cell Rep
. 2023 Apr;
42(4):112392.
PMID: 37058410
Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these effects are not fully understood, and here, we...
8.
Yang J, Vamvini M, Nigro P, Ho L, Galani K, Alvarez M, et al.
Cell Metab
. 2022 Oct;
34(10):1578-1593.e6.
PMID: 36198295
Exercise training is critical for the prevention and treatment of obesity, but its underlying mechanisms remain incompletely understood given the challenge of profiling heterogeneous effects across multiple tissues and cell...
9.
Hernandez-Saavedra D, Markunas C, Takahashi H, Baer L, Harris J, Hirshman M, et al.
Diabetes
. 2022 Jul;
71(10):2094-2105.
PMID: 35838316
That maternal and paternal exercise improve the metabolic health of adult offspring is well established. Tissue and serum metabolites play a fundamental role in the health of an organism, but...
10.
Alves-Wagner A, Kusuyama J, Nigro P, Ramachandran K, Makarewicz N, Hirshman M, et al.
Mol Metab
. 2022 Apr;
60:101490.
PMID: 35398278
Objective: A major factor in the growing world-wide epidemic of obesity and type 2 diabetes is the increased risk of transmission of metabolic disease from obese mothers to both first...