Eric A Ortlund
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Explore the profile of Eric A Ortlund including associated specialties, affiliations and a list of published articles.
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119
Citations
3766
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Recent Articles
1.
Kumar S, Moral-Sanchez I, Singh S, Newby M, Allen J, Bijl T, et al.
Vaccines (Basel)
. 2025 Feb;
13(2).
PMID: 40006657
Background: Elite-neutralizer-derived HIV-1 envelopes (Envs), which induce broadly neutralizing antibodies (bnAbs), can inform HIV-1 vaccine design by serving as templates for bnAb-eliciting vaccines. Since single Env-based immunizations are insufficient to...
2.
Rostad C, Yildirim I, Kao C, Yi J, Kamidani S, Peters E, et al.
NPJ Vaccines
. 2024 Dec;
9(1):255.
PMID: 39715748
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple...
3.
Weinberg J, Liu K, Lee C, Crandall W, Cuevas A, Druzak S, et al.
J Biol Chem
. 2024 Dec;
301(1):108074.
PMID: 39675709
The recently discovered microbiome-generated obesogen, δ-valerobetaine (5-(trimethylammonio)pentanoate), is a 5-carbon structural analog of the carnitine precursor, γ-butyrobetaine. Here, we report that δ-valerobetaine is enzymatically hydroxylated by mammalian γ-butyrobetaine dioxygenase (BBOX)...
4.
Keen M, Keith A, Ortlund E
J Biol Chem
. 2024 Dec;
301(1):108072.
PMID: 39674321
Epitope mapping is a technique employed to define the region of an antigen that elicits an immune response, providing crucial insight into the structural architecture of the antigen as well...
5.
Cuevas A, Tillman M, Wang M, Ortlund E
Protein Sci
. 2024 Dec;
34(1):e5249.
PMID: 39660930
Intracellular lipid binding proteins (iLBPs) play crucial roles in lipid transport and cellular metabolism across the animal kingdom. Recently, a fat-to-neuron axis was described in Caenorhabditis elegans, in which lysosomal...
6.
Blanchard J, Akay L, Davila-Velderrain J, von Maydell D, Mathys H, Davidson S, et al.
Nature
. 2024 Dec;
636(8043):E9.
PMID: 39633058
No abstract available.
7.
Xie Y, Liu X, Liu W, Carr L, Lee L, Imai N, et al.
J Biol Chem
. 2024 Oct;
300(11):107855.
PMID: 39369989
Thioesterase superfamily member 2 (Them2), a long-chain fatty acyl-CoA thioesterase that is highly expressed in oxidative tissues, interacts with phosphatidylcholine transfer protein (PC-TP) to regulate hepatic lipid and glucose metabolism...
8.
Kumar S, Moral-Sanchez I, Singh S, Newby M, Allen J, Bijl T, et al.
bioRxiv
. 2024 Sep;
PMID: 39345501
Various design platforms are available to stabilize soluble HIV-1 envelope (Env) trimers, which can be used as antigenic baits and vaccine antigens. However, stabilizing HIV-1 clade C trimers can be...
9.
Little M, Ortlund E
Biochem Soc Trans
. 2024 Aug;
52(4):1565-1577.
PMID: 39140379
Lipid synthesis and transport are essential for energy, production of cell membrane, and cell signaling. Acyl-CoA thioesterases (ACOTs) function to regulate intracellular levels of fatty acyl-CoAs through hydrolysis. Two members...
10.
Soto-Avellaneda A, Oxford A, Halla F, Vasquez P, Oe E, Pugel A, et al.
PLoS One
. 2024 Jun;
19(6):e0300168.
PMID: 38900831
The motor features of Parkinson's disease result from loss of dopaminergic neurons in the substantia nigra with autophagy dysfunction being closely linked to this disease. While a large body of...