Layer-Specific FMRI Responses to Excitatory and Inhibitory Neuronal Activities in the Olfactory Bulb

Overview

Journal J Neurosci

Specialty Neurology

Date 2015 Nov 21

PMID 26586815

Citations 41

Authors

Alexander John Poplawsky

Mitsuhiro Fukuda

Matthew Murphy

Seong-Gi Kim

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Functional magnetic resonance imaging (fMRI) is a noninvasive, in vivo technique widely used to map function of the entire brain, including deep structures, in animals and humans. However, it measures neuronal activity indirectly by way of the vascular response. It is currently unclear how finely the hemodynamic response is regulated within single cortical layers and whether increased inhibitory neuronal activities affect fMRI signal changes. Both laminar specificity and the neural origins of fMRI are important to interpret functional maps properly, which we investigated by activating discrete rat olfactory bulb circuits.

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